PF 573228
- Product Name
- PF 573228
- CAS No.
- 869288-64-2
- Chemical Name
- PF 573228
- Synonyms
- PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;Focal Adhesion Kinase Inhibitor II;PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II;Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
- CBNumber
- CB42459138
- Molecular Formula
- C22H20F3N5O3S
- Formula Weight
- 491.49
- MOL File
- 869288-64-2.mol
PF 573228 Property
- Melting point:
- >242°C (dec.)
- Density
- 1.459
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 14.30±0.20(Predicted)
- color
- white to off-white
- InChIKey
- HESLKTSGTIBHJU-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0117
- Product name
- PF-573228
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $147
- Updated
- 2024/03/01
- Product number
- 324878
- Product name
- Focal Adhesion Kinase Inhibitor II
- Packaging
- 10mg
- Price
- $233
- Updated
- 2022/05/15
- Product number
- 14924
- Product name
- PF-573228
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14924
- Product name
- PF-573228
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- PZ0117
- Product name
- PF-573228
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $576
- Updated
- 2024/03/01
PF 573228 Chemical Properties,Usage,Production
Description
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.
Uses
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.
Definition
ChEBI: 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one is a member of quinolines.
Biochem/physiol Actions
PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.
storage
Store at +4°C
References
[1]. slack-davis, j.k., et al., cellular characterization of a novel focal adhesion kinase inhibitor. j biol chem, 2007. 282(20): p. 14845-52.
[2]. golubovskaya, v.m., focal adhesion kinase as a cancer therapy target. anticancer agents med chem, 2010. 10(10): p. 735-41.
[3]. cabrita, m.a., et al., focal adhesion kinase inhibitors are potent anti-angiogenic agents. mol oncol, 2011. 5(6): p. 517-26.
[4]. al-toub, m., et al., pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells. stem cell res ther, 2013. 4(5): p. 114.
[5]. so, e.c., et al., evidence for activation of bk ca channels by a known inhibitor of focal adhesion kinase, pf573228. life sci, 2011. 89(19-20): p. 691-701.
PF 573228 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 573228 Suppliers
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- Fax
- 86-21-57758967
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- China
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- E-Mail Inquiry
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- Country
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View Lastest Price from PF 573228 manufacturers
- Product
- PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone 869288-64-2
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08