3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

Product Name: 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
CAS No.: 198474-05-4
Chemical Name: 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
Synonyms: EOS200271;PF-06840003;PF-06840003 (racemate);PF 06840003;PF-06840003;3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione;2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-
CBNumber: CB12523559
Molecular Formula: C12H9FN2O2
Formula Weight: 232.21
MOL File: 198474-05-4.mol

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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25003
Product name: EOS200271
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2023/01/06

Cayman Chemical

Product number: 25003
Product name: EOS200271
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2023/01/06

Cayman Chemical

Product number: 25003
Product name: EOS200271
Purity: ≥98%
Packaging: 10mg
Price: $247
Updated: 2023/01/06

Cayman Chemical

Product number: 25003
Product name: EOS200271
Purity: ≥98%
Packaging: 25mg
Price: $474
Updated: 2023/01/06

TRC

Product number: P293790
Product name: PF-06840003
Packaging: 1g
Price: $735
Updated: 2021/12/16

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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Usage,Production

Description

PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3

Uses

PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.

References

1) Crosignani?et al.?(2017),?Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate;?J. Med. Chem.?60?9617 2) Gomes?et al.?(2018),?Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy;?Mol. Cancer Ther.?9?2530 3) Blair?et al.?(2019),?IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma;?J. Clin. Invest.?129?1742

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Suppliers

China 65 India 1 United Kingdom 1 United States 6 Global 73

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Shanghai Balmxy Pharmaceutical Co., Ltd

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Hangzhou J&H Chemical Co., Ltd.

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View Lastest Price from 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione manufacturers

Career Henan Chemical Co

Product: 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 198474-05-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

198474-05-4, 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dioneRelated Search:

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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione

PF-06840003

2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-

3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione

PF-06840003 (racemate)

EOS200271

PF 06840003;PF-06840003

198474-05-4

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