PF-04979064

Product Name: PF-04979064
CAS No.: 1220699-06-8
Chemical Name: PF-04979064
Synonyms: CS-2664;PF-04979064;PF-04979064 ≥95%;PF 04979064;PF04979064;PF-04979064 >=98% (HPLC);PF-04979064, 10 mM in DMSO;Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,PF 04979064,PF04979064,mTOR,PF-04979064,PI3K,inhibit;(S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one;1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1H,2H,3H-imidazo[4,5-c]1,5-naphthyridin-2-one;(S)-1-(1-(2-Hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
CBNumber: CB32714676
Molecular Formula: C24H26N6O3
Formula Weight: 446.5
MOL File: 1220699-06-8.mol

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PF-04979064 Property

Boiling point:: 682.0±55.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 11 mg/mL (24.64 mM)
form: Solid
pka: 13.95±0.20(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5697
Product name: PF-04979064
Purity: 99.75%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-5697
Product name: PF-04979064
Purity: 99.75%
Packaging: 10mg
Price: $156
Updated: 2021/12/16

ChemScene

Product number: CS-5697
Product name: PF-04979064
Purity: 99.75%
Packaging: 25mg
Price: $348
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1194-M005
Product name: PF-04979064
Purity: ≥95%
Packaging: 5mg
Price: $416
Updated: 2021/12/16

ChemScene

Product number: CS-5697
Product name: PF-04979064
Purity: 99.75%
Packaging: 50mg
Price: $624
Updated: 2021/12/16

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PF-04979064 Chemical Properties,Usage,Production

Uses

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

Biological Activity

PF-04979064 is an orally available, potent and selective PI3K/mTOR dual kinase inhibitor th at potently inhibits tumor growth in mouse xenografts.

in vivo

PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T_1/2=1.85 h, and F%=61%^[1].

IC 50

PI3Kα: 0.13 nM (Ki); PI3Kγ: 0.111 nM (Ki); PI3Kδ: 0.122 nM (Ki); mTOR: 1.42 nM (Ki)

References

[1] Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7. DOI:10.1021/ml300309h

PF-04979064 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-04979064 Suppliers

CHINA 60 United Kingdom 1 United States 5 Global 66

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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1220699-06-8, PF-04979064Related Search:

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PF-04979064

(S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one

CS-2664

PF-04979064 ≥95%

PF 04979064;PF04979064

2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-

PF-04979064 >=98% (HPLC)

1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one

Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,PF 04979064,PF04979064,mTOR,PF-04979064,PI3K,inhibit

(S)-1-(1-(2-Hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one

1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1H,2H,3H-imidazo[4,5-c]1,5-naphthyridin-2-one

PF-04979064, 10 mM in DMSO

1220699-06-8