PF-9366

Product Name: PF-9366
CAS No.: 72882-78-1
Chemical Name: PF-9366
Synonyms: CS-2703;PF-9366;PF 9366 NEW;PF-9366 ，S0435;PF-9366, 10 mM in DMSO;PF-9366; PF 9366; PF9366;72882-78-1;PF-9366,inhibit,PF9366,PF 9366,Inhibitor;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
CBNumber: CB13375661
Molecular Formula: C20H19ClN4
Formula Weight: 350.84
MOL File: 72882-78-1.mol

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PF-9366 Property

Melting point:: 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 20 mg/ml).
pka: 8.75±0.28(Predicted)
form: solid
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 25mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 10mg
Price: $152
Updated: 2024/03/01

TRC

Product number: P294108
Product name: PF-9366
Packaging: 10mg
Price: $825
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP164086
Product name: PF 9366 NEW
Packaging: 10mg
Price: $125
Updated: 2021/12/16

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PF-9366 Chemical Properties,Usage,Production

Description

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.

Uses

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.

References

[1] CASEY L QUINLAN. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A[J]. Nature chemical biology, 2017, 13 7: 785-792. DOI:10.1038/nchembio.2384

PF-9366 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-9366 Suppliers

China 59 United Kingdom 1 United States 10 Global 70

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29661
Advantage: 68

Shanghai BetterBioChem Co., Ltd.

Tel: +86-18017644823
Fax: - QQ：1910610264
Email: sales@betterbiochem.com
Country: China
ProdList: 325
Advantage: 58

Aikon International Limited

Tel: 025-66113011 19370895928
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15393
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

72882-78-1, PF-9366Related Search:

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF-3450074 PF-562271 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester PF 573228 PF 05105679

PF-9366

CS-2703

PF-9366; PF 9366; PF9366;72882-78-1

PF 9366 NEW

[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-

2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine

PF-9366,inhibit,PF9366,PF 9366,Inhibitor

PF-9366, 10 mM in DMSO

PF-9366 ，S0435

72882-78-1

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