ChemicalBook > CAS DataBase List > PF-9366

PF-9366

Product Name: PF-9366
CAS No.: 72882-78-1
Chemical Name: PF-9366
Synonyms: CS-2703;PF-9366;PF 9366 NEW;PF-9366 ，S0435;PF-9366, 10 mM in DMSO;PF-9366; PF 9366; PF9366;72882-78-1;PF-9366,inhibit,PF9366,PF 9366,Inhibitor;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
CBNumber: CB13375661
Molecular Formula: C20H19ClN4
Formula Weight: 350.84
MOL File: 72882-78-1.mol

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PF-9366 Property

Melting point:: 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 20 mg/ml).
pka: 8.75±0.28(Predicted)
form: solid
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 25mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 30782
Product name: PF-9366
Packaging: 10mg
Price: $152
Updated: 2024/03/01

TRC

Product number: P294108
Product name: PF-9366
Packaging: 10mg
Price: $825
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP164086
Product name: PF 9366 NEW
Packaging: 10mg
Price: $125
Updated: 2021/12/16

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PF-9366 Chemical Properties,Usage,Production

Description

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.

Uses

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.

References

[1] CASEY L QUINLAN. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A[J]. Nature chemical biology, 2017, 13 7: 785-792. DOI:10.1038/nchembio.2384

PF-9366 Preparation Products And Raw materials

Raw materials

Preparation Products

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72882-78-1, PF-9366Related Search:

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF-3450074 PF-562271 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester PF 573228 PF 05105679

PF-9366

CS-2703

PF-9366; PF 9366; PF9366;72882-78-1

PF 9366 NEW

[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-

2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine

PF-9366,inhibit,PF9366,PF 9366,Inhibitor

PF-9366, 10 mM in DMSO

PF-9366 ，S0435

72882-78-1

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