PF-3450074

Product Name: PF-3450074
CAS No.: 1352879-65-2
Chemical Name: PF-3450074
Synonyms: PF74;PF-3450074;PF 3450074;PF74 >=98% (HPLC);PF-3450074, 10 mM in DMSO;(S)-N-Methyl-2-(2-(2-methyl-1H-indol-3-yl)acetamido)-N,3-diphenylpropanamide;(2S)-N-methyl-2-[2-(2-methyl-1H-indol-3-yl)acetamido]-N,3-diphenylpropanamide;2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide;1H-Indole-3-acetamide, 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]-;capsid protein,inhibit,PBMC,PF74,Human immunodeficiency virus,Inhibitor,PF-3450074,PF 3450074,PF 74,HIV,PF3450074
CBNumber: CB82751081
Molecular Formula: C27H27N3O2
Formula Weight: 425.52
MOL File: 1352879-65-2.mol

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PF-3450074 Property

storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0835
Product name: PF74
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0835
Product name: PF74
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $492
Updated: 2025/07/31

ChemScene

Product number: CS-0069433
Product name: PF-3450074
Purity: 99.20%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

AK Scientific

Product number: SYN5021
Product name: PF74
Packaging: 100mg
Price: $730
Updated: 2021/12/16

ChemScene

Product number: CS-0069433
Product name: PF-3450074
Purity: 99.20%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

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PF-3450074 Chemical Properties,Usage,Production

Uses

PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

Biological Activity

PF74 (PF-3450074) is a HIV-1 inhibitor th at targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells.

IC 50

HIV-1 (NL4.3 strain): 0.72 μM (IC₅₀)

References

[1] Xu JP, et al. Exploring?Modifications?of an?HIV-1?Capsid?Inhibitor:?Design,?Synthesis, and?Mechanism?of?Action.J Drug Des Res.?2018;5(2). pii: 1070. Epub 2018 Aug 13. PMID:30393786
[2] Shi J, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.J Virol. 2011 Jan;85(1):542-9. DOI:10.1128/JVI.01406-10

PF-3450074 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-3450074 Suppliers

China 44 United Kingdom 1 United States 5 Global 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9119
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

1352879-65-2, PF-3450074Related Search:

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2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide

PF 3450074

PF-3450074

PF74

1H-Indole-3-acetamide, 2-methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]-

PF74 >=98% (HPLC)

(S)-N-Methyl-2-(2-(2-methyl-1H-indol-3-yl)acetamido)-N,3-diphenylpropanamide

capsid protein,inhibit,PBMC,PF74,Human immunodeficiency virus,Inhibitor,PF-3450074,PF 3450074,PF 74,HIV,PF3450074

(2S)-N-methyl-2-[2-(2-methyl-1H-indol-3-yl)acetamido]-N,3-diphenylpropanamide

PF-3450074, 10 mM in DMSO

1352879-65-2