ChemicalBook > CAS DataBase List > PF-562271

PF-562271

Product Name
PF-562271
CAS No.
939791-38-5
Chemical Name
PF-562271
Synonyms
PF-00562271, >=98%;PF-562271 (besylate);PF-00562271 Besylate;PF-562271 PhSO3H salt;PF-00562271 (PF-562271);PF-562271 benzenesulfonate;LKLWTLXTOVZFAE-UHFFFAOYSA-N;PF-562271 besylate PF562271;PF 562271 Benzenesulfonic acid;PF-562271 benzenesulfonate salt
CBNumber
CB22535568
Molecular Formula
C27H26F3N7O6S2
Formula Weight
665.66
MOL File
939791-38-5.mol
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PF-562271 Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL in DMSO with gentle warming
form 
solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18499
Product name
PF-562271 (besylate)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
18499
Product name
PF-562271 (besylate)
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
18499
Product name
PF-562271 (besylate)
Purity
≥98%
Packaging
10mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
18499
Product name
PF-562271 (besylate)
Purity
≥98%
Packaging
50mg
Price
$775
Updated
2024/03/01
TRC
Product number
P293925
Product name
PF562271Besylate
Packaging
100mg
Price
$1040
Updated
2021/12/16
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PF-562271 Chemical Properties,Usage,Production

Description

Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) are non-receptor tyrosine kinases that constitute the FAK subfamily and play a vital role in many oncogenic pathways. PF-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) that demonstrates 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases. PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models.

Uses

A potent, ATP-competitive and reversible inhibitor of FAK and Pyk2 catalytic activity with IC50s of 1.5 nM and 14 nM, respectively.

Uses

PF 562271 Besylate is the besylate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK).

target

FAK

References

[1]stokes jb, adair sj, slack-davis jk, walters dm, tilghman rw, hershey ed, lowrey b, thomas ks, bouton ah, hwang rf, stelow eb, parsons jt, bauer tw. inhibition of focal adhesion kinase by pf-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. mol cancer ther. 2011 nov;10(11):2135-45. doi: 10.1158/1535-7163.mct-11-0261. epub 2011 sep 8.
[2]roberts wg, ung e, whalen p, cooper b, hulford c, autry c, richter d, emerson e, lin j, kath j, coleman k, yao l, martinez-alsina l, lorenzen m, berliner m, luzzio m, patel n, schmitt e, lagreca s, jani j, wessel m, marr e, griffor m, vajdos f. antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, pf-562,271. cancer res. 2008 mar 15;68(6):1935-44. doi: 10.1158/0008-5472.can-07-5155.

PF-562271 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-562271 Suppliers

Wuhan Candichem Medical Technology Co.,Ltd.
Tel
13476791851
Email
1972919443@qq.com
Country
China
ProdList
122
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ExcelChemical (Shanghai) Chemical Technology Co., Ltd.
Tel
+86 13671938079
Fax
+86-021-50829787
Country
China
ProdList
39
Advantage
55

939791-38-5, PF-562271Related Search:


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  • PF-562271 benzenesulfonate salt
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  • PF-562271 benzenesulfonate
  • PF-00562271 benzenesulfonate salt
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  • LKLWTLXTOVZFAE-UHFFFAOYSA-N
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  • PF562271 BESYLATE;PF 562271 BESYLATE
  • PF-00562271 Besylate
  • PF-562271 (benzesulfonate salt)
  • PF-562271 besylate PF562271
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