6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
- Product Name
- 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
- CAS No.
- 1467057-23-3
- Chemical Name
- 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
- Synonyms
- CS-2760;EOS-61684;PF 6409577;PF-06409577;PF 06409577;PF06409577;PF-06409577 >=98% (HPLC);PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-;Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit
- CBNumber
- CB33142869
- Molecular Formula
- C19H16ClNO3
- Formula Weight
- 341.79
- MOL File
- 1467057-23-3.mol
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Property
- Boiling point:
- 610.9±55.0 °C(Predicted)
- Density
- 1.468±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble
- form
- powder
- pka
- 3.60±0.30(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0319
- Product name
- PF-06409577
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- PZ0319
- Product name
- PF-06409577
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
- Product number
- 27366
- Product name
- PF-06409577
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 27366
- Product name
- PF-06409577
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 27366
- Product name
- PF-06409577
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Chemical Properties,Usage,Production
Description
PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.
Uses
PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.
General Description
PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.
Biochem/physiol Actions
PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis.
storage
Store at RT
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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