ChemicalBook > CAS DataBase List > 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

Product Name
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
CAS No.
1467057-23-3
Chemical Name
6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
Synonyms
CS-2760;EOS-61684;PF 6409577;PF-06409577;PF 06409577;PF06409577;PF-06409577 >=98% (HPLC);PF-06409577;PF 06409577;PF06409577;6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-;Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit
CBNumber
CB33142869
Molecular Formula
C19H16ClNO3
Formula Weight
341.79
MOL File
1467057-23-3.mol
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6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Property

Boiling point:
610.9±55.0 °C(Predicted)
Density 
1.468±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble
form 
powder
pka
3.60±0.30(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0319
Product name
PF-06409577
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0319
Product name
PF-06409577
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
27366
Product name
PF-06409577
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
27366
Product name
PF-06409577
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
27366
Product name
PF-06409577
Packaging
1mg
Price
$32
Updated
2024/03/01
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6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Chemical Properties,Usage,Production

Description

PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.

Uses

PF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.

General Description

PF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.

Biochem/physiol Actions

PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis.

storage

Store at RT

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid Suppliers

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1467057-23-3, 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacidRelated Search:

PF 03463275 PF-06446846 HYDROCHLORIDE PF-CBP-1.HCl PF 05105679 N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

  • CS-2760
  • PF-06409577;PF 06409577;PF06409577
  • 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid
  • PF-06409577
  • EOS-61684
  • PF 06409577;PF06409577
  • PF 6409577
  • 1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-
  • PF-06409577 >=98% (HPLC)
  • Inhibitor,AMP-activated protein kinase,PF-06409577,AMPK,PF06409577,inhibit
  • 1467057-23-3