PF 03463275

Product Name: PF 03463275
CAS No.: 1173239-39-8
Chemical Name: PF 03463275
Synonyms: PF0346275;PF-03463275, 10 mM in DMSO;1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-;1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-
CBNumber: CB45984147
Molecular Formula: C19H22ClFN4O
Formula Weight: 376.86
MOL File: 1173239-39-8.mol

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PF 03463275 Property

Melting point:: 125 °C
Boiling point:: 575.8±45.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 33.33 mg/mL (88.44 mM)
pka: 10.07±0.40(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FP104276
Product name: PF 03463275 NEW
Packaging: 10mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-0087733
Product name: PF-03463275
Purity: 99.57%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0087733
Product name: PF-03463275
Purity: 99.57%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP104276
Product name: PF 03463275 NEW
Packaging: 50mg
Price: $472.5
Updated: 2021/12/16

ChemScene

Product number: CS-0087733
Product name: PF-03463275
Purity: 99.57%
Packaging: 50mg
Price: $600
Updated: 2021/12/16

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PF 03463275 Chemical Properties,Usage,Production

Uses

PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 has the potential for Schizophrenia research[1][2].

in vivo

PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs)^[2].

Animal Model:	Male Sprague-Dawley rats^[2]
Dosage:	1, 3 and 10 mg/kg
Administration:	S.c.
Result:	A dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from the dark-adapted rats.

IC 50

GlyT1

References

[1] Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19(11):2974-2976. DOI:10.1016/j.bmcl.2009.04.035
[2] Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211. DOI:10.3109/15569527.2013.833937

PF 03463275 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 03463275 Suppliers

China 19 United States 2 Global 21

Shanghai EFE Biological Technology Co., Ltd.

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PF0346275

1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-

PF-03463275, 10 mM in DMSO

1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1α,5α,6α)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-

1173239-39-8

C19H22ClFN4O