PF 05105679

Product Name: PF 05105679
CAS No.: 1398583-31-7
Chemical Name: PF 05105679
Synonyms: PF 05105679;PF-05105679 >=98% (HPLC);PF-05105679, 10 mM in DMSO;(R)-3-((N-(1-(4-Fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid;3-[[[(1R)-1-(4-Fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]benzoic acid;Benzoic acid, 3-[[[(1R)-1-(4-fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]-;Inhibitor,TRPM8,PF05105679,subfamily,cold-related,orally,clinical,menthol,TRP Channel,PF-05105679,pain,Transient receptor potential channels,PF 05105679,inhibit,cold,CMR1,melastatin
CBNumber: CB43146354
Molecular Formula: C26H21FN2O3
Formula Weight: 428.45
MOL File: 1398583-31-7.mol

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PF 05105679 Property

Boiling point:: 669.0±55.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: 10 mg/ml
form: powder
pka: 4.14±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0245
Product name: PF-05105679
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0245
Product name: PF-05105679
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Cayman Chemical

Product number: 29489
Product name: PF-05105679
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29489
Product name: PF-05105679
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29489
Product name: PF-05105679
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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PF 05105679 Chemical Properties,Usage,Production

Biological Activity

PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.', 'PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) antagonist, PF-05105679 [(R)-3-[(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)amino]methylbenzoic acid] acts as a clinical tool to assess the function of TRPM8 in modulating the body temperature. It also helps to determine its role in the treatment of pain in humans.

PF 05105679 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 05105679 Suppliers

China 33 United Kingdom 1 United States 4 Global 38

Shanghai Lollane Biological Technology Co.,Ltd.

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PF 05105679

3-[[[(1R)-1-(4-Fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]benzoic acid

Benzoic acid, 3-[[[(1R)-1-(4-fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]-

PF-05105679 >=98% (HPLC)

Inhibitor,TRPM8,PF05105679,subfamily,cold-related,orally,clinical,menthol,TRP Channel,PF-05105679,pain,Transient receptor potential channels,PF 05105679,inhibit,cold,CMR1,melastatin

(R)-3-((N-(1-(4-Fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid

PF-05105679, 10 mM in DMSO

1398583-31-7