PF-06446846 HYDROCHLORIDE

Product Name: PF-06446846 HYDROCHLORIDE
CAS No.: 1632250-50-0
Chemical Name: PF-06446846 HYDROCHLORIDE
Synonyms: PF 6446846 hydrochloride;PF-06446846 HYDROCHLORIDE;PF-06446846 hydrochloride >=98% (HPLC);PF06446846 hydrochloride,PF 06446846 hydrochloride;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
CBNumber: CB44744339
Molecular Formula: C22H21Cl2N7O
Formula Weight: 470.36
MOL File: 1632250-50-0.mol

More

Less

PF-06446846 HYDROCHLORIDE Property

storage temp.: room temp
solubility: DMSO : 250 mg/mL (531.52 mM)
form: powder
color: white to beige
optical activity: [α]/D -60 to -50°, c = 1 in methanol

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0374
Product name: PF-06446846 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $100.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0374
Product name: PF-06446846 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $674
Updated: 2024/03/01

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 50mg
Price: $1200
Updated: 2021/12/16

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 100mg
Price: $2100
Updated: 2021/12/16

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

More

Less

PF-06446846 HYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.

in vitro

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC ₅₀ of 0.3 μM.

in vivo

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

Animal Model:	Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)
Dosage:	5, 15, and 50 mg/kg
Administration:	Oral gavage; daily for 14 days
Result:	Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.

target

PCSK9

PF-06446846 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PF-06446846 HYDROCHLORIDE Suppliers

China 18 Japan 1 United States 4 Global 23

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 918
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

1632250-50-0, PF-06446846 HYDROCHLORIDERelated Search:

4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester PF 03463275 PF-CBP-1.HCl PF 05105679 N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

PF-06446846 HYDROCHLORIDE

N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride

PF 6446846 hydrochloride

PF-06446846 hydrochloride >=98% (HPLC)

PF06446846 hydrochloride,PF 06446846 hydrochloride

(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride

1632250-50-0