PF-06446846 HYDROCHLORIDE

Product Name: PF-06446846 HYDROCHLORIDE
CAS No.: 1632250-50-0
Chemical Name: PF-06446846 HYDROCHLORIDE
Synonyms: PF-0644684;PF 6446846 hydrochloride;PF-06446846 HYDROCHLORIDE;PF-06446846 hydrochloride >=98% (HPLC);PF-06446846 hydrochloride, 10 mM in DMSO;PF06446846 hydrochloride,PF 06446846 hydrochloride;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
CBNumber: CB44744339
Molecular Formula: C22H21Cl2N7O
Formula Weight: 470.36
MOL File: 1632250-50-0.mol

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PF-06446846 HYDROCHLORIDE Property

storage temp.: room temp
solubility: DMSO : 250 mg/mL (531.52 mM)
form: powder
color: white to beige
optical activity: [α]/D -60 to -50°, c = 1 in methanol
Water Solubility: H2O: 2mg/mL, clear

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0374
Product name: PF-06446846 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $156.34
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0374
Product name: PF-06446846 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $693
Updated: 2025/07/31

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 50mg
Price: $1200
Updated: 2021/12/16

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 100mg
Price: $2100
Updated: 2021/12/16

ChemScene

Product number: CS-0085754
Product name: PF-06446846 hydrochloride
Purity: 98.03%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

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PF-06446846 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].

Biological Activity

PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.

in vitro

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC ₅₀ of 0.3 μM.

in vivo

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

Animal Model:	Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)
Dosage:	5, 15, and 50 mg/kg
Administration:	Oral gavage; daily for 14 days
Result:	Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.

target

PCSK9

References

[1] Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882. DOI:10.1371/journal.pbio.2001882

PF-06446846 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06446846 HYDROCHLORIDE Suppliers

China 28 Japan 1 United States 4 Global 33

Shanghai Lollane Biological Technology Co.,Ltd.

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1632250-50-0, PF-06446846 HYDROCHLORIDERelated Search:

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PF-06446846 HYDROCHLORIDE

N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride

PF 6446846 hydrochloride

PF-06446846 hydrochloride >=98% (HPLC)

PF06446846 hydrochloride,PF 06446846 hydrochloride

(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride

PF-06446846 hydrochloride, 10 mM in DMSO

PF-0644684

1632250-50-0