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PF-06446846 HYDROCHLORIDE

Product Name
PF-06446846 HYDROCHLORIDE
CAS No.
1632250-50-0
Chemical Name
PF-06446846 HYDROCHLORIDE
Synonyms
PF 6446846 hydrochloride;PF-06446846 HYDROCHLORIDE;PF-06446846 hydrochloride >=98% (HPLC);PF06446846 hydrochloride,PF 06446846 hydrochloride;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
CBNumber
CB44744339
Molecular Formula
C22H21Cl2N7O
Formula Weight
470.36
MOL File
1632250-50-0.mol
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PF-06446846 HYDROCHLORIDE Property

storage temp. 
room temp
solubility 
DMSO : 250 mg/mL (531.52 mM)
form 
powder
color 
white to beige
optical activity
[α]/D -60 to -50°, c = 1 in methanol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0374
Product name
PF-06446846 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$100.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0374
Product name
PF-06446846 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$674
Updated
2024/03/01
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
50mg
Price
$1200
Updated
2021/12/16
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
100mg
Price
$2100
Updated
2021/12/16
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
5mg
Price
$250
Updated
2021/12/16
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PF-06446846 HYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.

in vitro

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC 50 of 0.3 μM.

in vivo

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

Animal Model: Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)
Dosage: 5, 15, and 50 mg/kg
Administration: Oral gavage; daily for 14 days
Result: Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.

target

PCSK9

PF-06446846 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06446846 HYDROCHLORIDE Suppliers

China 18 Japan 1 United States 4 Global 23
Sigma-Aldrich Japan K.K.
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Fax
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Email
sialjp@sial.com
Country
Japan
ProdList
5753
Advantage
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1632250-50-0, PF-06446846 HYDROCHLORIDERelated Search:

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  • PF-06446846 HYDROCHLORIDE
  • N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
  • PF 6446846 hydrochloride
  • PF-06446846 hydrochloride >=98% (HPLC)
  • PF06446846 hydrochloride,PF 06446846 hydrochloride
  • (R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride
  • 1632250-50-0