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PF-06446846 HYDROCHLORIDE

Product Name
PF-06446846 HYDROCHLORIDE
CAS No.
1632250-50-0
Chemical Name
PF-06446846 HYDROCHLORIDE
Synonyms
PF 6446846 hydrochloride;PF-06446846 HYDROCHLORIDE;PF-06446846 hydrochloride >=98% (HPLC);PF06446846 hydrochloride,PF 06446846 hydrochloride;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
CBNumber
CB44744339
Molecular Formula
C22H21Cl2N7O
Formula Weight
470.36
MOL File
1632250-50-0.mol
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PF-06446846 HYDROCHLORIDE Property

storage temp. 
room temp
solubility 
DMSO : 250 mg/mL (531.52 mM)
form 
powder
color 
white to beige
optical activity
[α]/D -60 to -50°, c = 1 in methanol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0374
Product name
PF-06446846 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$100.8
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0374
Product name
PF-06446846 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$674
Updated
2024/03/01
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
50mg
Price
$1200
Updated
2021/12/16
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
100mg
Price
$2100
Updated
2021/12/16
ChemScene
Product number
CS-0085754
Product name
PF-06446846 hydrochloride
Purity
98.03%
Packaging
5mg
Price
$250
Updated
2021/12/16
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PF-06446846 HYDROCHLORIDE Chemical Properties,Usage,Production

Biological Activity

PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.

in vitro

PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC 50 of 0.3 μM.

in vivo

PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

Animal Model: Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)
Dosage: 5, 15, and 50 mg/kg
Administration: Oral gavage; daily for 14 days
Result: Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.

target

PCSK9

PF-06446846 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06446846 HYDROCHLORIDE Suppliers

China 18 Japan 1 United States 4 Global 23
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7268
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
918
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62163
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6813
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58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29977
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58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9272
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58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
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60
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
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Email
info@zzsrm.com
Country
CHINA
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6650
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58

1632250-50-0, PF-06446846 HYDROCHLORIDERelated Search:

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  • PF-06446846 HYDROCHLORIDE
  • N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
  • PF 6446846 hydrochloride
  • PF-06446846 hydrochloride >=98% (HPLC)
  • PF06446846 hydrochloride,PF 06446846 hydrochloride
  • (R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride
  • 1632250-50-0