ChemicalBook > CAS DataBase List > PF-04979064

PF-04979064

Product Name
PF-04979064
CAS No.
1220699-06-8
Chemical Name
PF-04979064
Synonyms
CS-2664;PF-04979064;PF-04979064 ≥95%;PF 04979064;PF04979064;PF-04979064 >=98% (HPLC);PF-04979064, 10 mM in DMSO;Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,PF 04979064,PF04979064,mTOR,PF-04979064,PI3K,inhibit;(S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one;1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1H,2H,3H-imidazo[4,5-c]1,5-naphthyridin-2-one;(S)-1-(1-(2-Hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
CBNumber
CB32714676
Molecular Formula
C24H26N6O3
Formula Weight
446.5
MOL File
1220699-06-8.mol
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PF-04979064 Property

Boiling point:
682.0±55.0 °C(Predicted)
Density 
1.355±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 11 mg/mL (24.64 mM)
form 
Solid
pka
13.95±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5697
Product name
PF-04979064
Purity
99.75%
Packaging
5mg
Price
$96
Updated
2021/12/16
ChemScene
Product number
CS-5697
Product name
PF-04979064
Purity
99.75%
Packaging
10mg
Price
$156
Updated
2021/12/16
ChemScene
Product number
CS-5697
Product name
PF-04979064
Purity
99.75%
Packaging
25mg
Price
$348
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1194-M005
Product name
PF-04979064
Purity
≥95%
Packaging
5mg
Price
$416
Updated
2021/12/16
ChemScene
Product number
CS-5697
Product name
PF-04979064
Purity
99.75%
Packaging
50mg
Price
$624
Updated
2021/12/16
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PF-04979064 Chemical Properties,Usage,Production

Uses

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

Biological Activity

PF-04979064 is an orally available, potent and selective PI3K/mTOR dual kinase inhibitor th at potently inhibits tumor growth in mouse xenografts.

in vivo

PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1].

IC 50

PI3Kα: 0.13 nM (Ki); PI3Kγ: 0.111 nM (Ki); PI3Kδ: 0.122 nM (Ki); mTOR: 1.42 nM (Ki)

References

[1] Cheng H et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 2012 Nov 7, 4(1):91-7. DOI:10.1021/ml300309h

PF-04979064 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-04979064 Suppliers

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1220699-06-8, PF-04979064Related Search:

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  • PF-04979064
  • (S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one
  • CS-2664
  • PF-04979064 ≥95%
  • PF 04979064;PF04979064
  • 2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-
  • PF-04979064 >=98% (HPLC)
  • 1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
  • Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,PF 04979064,PF04979064,mTOR,PF-04979064,PI3K,inhibit
  • (S)-1-(1-(2-Hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c][1,5]naphthyridin-2-one
  • 1-{1-[(2S)-2-hydroxypropanoyl]piperidin-4-yl}-3-methyl-8-(6-methylpyridin-3-yl)-1H,2H,3H-imidazo[4,5-c]1,5-naphthyridin-2-one
  • PF-04979064, 10 mM in DMSO
  • 1220699-06-8