IDO-IN-1
- Product Name
- IDO-IN-1
- CAS No.
- 914638-30-5
- Chemical Name
- IDO-IN-1
- Synonyms
- CS-1532;DO-IN-1;IDO-IN-1;4-amino-N(3-bromo-4-fluorophenyl)-N-hydroxy-;Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO),IDO IN 1,IDOIN1;4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide;1,2,5-Oxadiazole-3-carboximidamide, 4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-;(E)-4-amino-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;(Z)-4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide;IDO-IN-1/4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
- CBNumber
- CB73041412
- Molecular Formula
- C9H7BrFN5O2
- Formula Weight
- 316.09
- MOL File
- 914638-30-5.mol
IDO-IN-1 Property
- Boiling point:
- 512.6±60.0 °C(Predicted)
- Density
- 2.03±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥29.1 mg/mL in DMSO; ≥25.9 mg/mL in EtOH; insoluble in H2O
- form
- crystalline solid
- pka
- 7.54±0.69(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19402
- Product name
- IDO-IN-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 19402
- Product name
- IDO-IN-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 19402
- Product name
- IDO-IN-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- C3211
- Product name
- IDO-IN-1
- Packaging
- 10mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- HCH0419840
- Product name
- (Z)-4-AMINO-N'-(3-BROMO-4-FLUOROPHENYL)-N-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXIMIDAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.54
- Updated
- 2021/12/16
IDO-IN-1 Chemical Properties,Usage,Production
Biological Activity
ido-in-1 is an indoleamine-2,3-dioxygenase (ido) inhibitor.ido is expressed in various tissues throughout the body but mainly in cells within the immune system where it is induced in dendritic cells and macrophages at sites of inflammation by cytokines. the overexpression of ido has been implicated in a variety of diseases, such as cancer, neurodegenerative disorders, age-related cataract, and hiv encephalitis.
in vitro
in previous study, ido-in-1 was found to have improved in-vitro human intrinsic clearances without loss in ido cellular potency [1].
in vivo
ido-in-1 analog, named 5l, was chosen for further in vivo studies because of its improved physical chemical properties compared to ido-in-1. the efficacy of 5l was tested in c57bl/6 mice with gmcsf-secreting b16 tumors, where 1-mt had previously shown activity. results showed that the dose-dependent inhibition of tumor growth was linked to increasing exposures of 5l in plasma. in addition, a maximal effect of 50% tumor growth control (tgc) was observed when 5l was subcutaneously administered at 75 mg/kg bid. for comparison, 1-mt showed around 45% tgc when administered as subcutaneous pellets [1].
IC 50
59 nm
References
[1] yue ew, et al. discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. j med chem. 2009 dec 10;52(23):7364-7.
IDO-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
IDO-IN-1 Suppliers
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- 86-21-57758967
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- China
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View Lastest Price from IDO-IN-1 manufacturers
- Product
- IDO-IN-1 914638-30-5
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-03-13