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8-Nitrotryptanthrin

Product Name
8-Nitrotryptanthrin
CAS No.
77603-42-0
Chemical Name
8-Nitrotryptanthrin
Synonyms
NF-PF-3777;GNF-PF-3777;8-Nitrotryptanthrin;GNF-PF-3777, 10 mM in DMSO;GNF-PF-3777 (8-Nitrotryptanthrin);8-Nitroindolo[2,1-b]quinazoline-6,12-dione;Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-;GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)
CBNumber
CB83155055
Molecular Formula
C15H7N3O4
Formula Weight
293.23
MOL File
77603-42-0.mol
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8-Nitrotryptanthrin Property

Melting point:
>250 °C
Boiling point:
551.2±52.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:4.2(Max Conc. mg/mL);14.32(Max Conc. mM)
form 
A crystalline solid
pka
-7.55±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28429
Product name
8-Nitrotryptanthrin
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28429
Product name
8-Nitrotryptanthrin
Packaging
25mg
Price
$1041
Updated
2024/03/01
Cayman Chemical
Product number
28429
Product name
8-Nitrotryptanthrin
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
28429
Product name
8-Nitrotryptanthrin
Packaging
10mg
Price
$477
Updated
2024/03/01
ChemScene
Product number
CS-6001
Product name
GNF-PF-3777
Purity
95.67%
Packaging
1mg
Price
$132
Updated
2021/12/16
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8-Nitrotryptanthrin Chemical Properties,Usage,Production

Uses

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

IC 50

rhIDO2: 1.8 μM (IC50); rhIDO2: 0.97 μM (Ki)

References

[1] Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. DOI:10.1016/j.ejmech.2016.07.013
[2] Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. DOI:10.1128/AAC.46.3.882-883.2002
[3] Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67. DOI:10.1021/np3007167

8-Nitrotryptanthrin Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Nitrotryptanthrin Suppliers

China 47 United States 8 Global 55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4757
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
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4660
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
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1886
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32435
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InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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6391
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Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9990
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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58

77603-42-0, 8-NitrotryptanthrinRelated Search:

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  • 8-Nitrotryptanthrin
  • GNF-PF-3777
  • Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-
  • GNF-PF-3777 (8-Nitrotryptanthrin)
  • GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)
  • 8-Nitroindolo[2,1-b]quinazoline-6,12-dione
  • NF-PF-3777
  • GNF-PF-3777, 10 mM in DMSO
  • 77603-42-0