ChemicalBook > CAS DataBase List > 8-Nitrotryptanthrin

8-Nitrotryptanthrin

Product Name: 8-Nitrotryptanthrin
CAS No.: 77603-42-0
Chemical Name: 8-Nitrotryptanthrin
Synonyms: NF-PF-3777;GNF-PF-3777;8-Nitrotryptanthrin;GNF-PF-3777, 10 mM in DMSO;GNF-PF-3777 (8-Nitrotryptanthrin);8-Nitroindolo[2,1-b]quinazoline-6,12-dione;Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-;GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)
CBNumber: CB83155055
Molecular Formula: C15H7N3O4
Formula Weight: 293.23
MOL File: 77603-42-0.mol

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8-Nitrotryptanthrin Property

Melting point:: >250 °C
Boiling point:: 551.2±52.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:4.2(Max Conc. mg/mL);14.32(Max Conc. mM)
form: A crystalline solid
pka: -7.55±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28429
Product name: 8-Nitrotryptanthrin
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28429
Product name: 8-Nitrotryptanthrin
Packaging: 25mg
Price: $1041
Updated: 2024/03/01

Cayman Chemical

Product number: 28429
Product name: 8-Nitrotryptanthrin
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 28429
Product name: 8-Nitrotryptanthrin
Packaging: 10mg
Price: $477
Updated: 2024/03/01

AK Scientific

Product number: 3458CC
Product name: 8-Nitroindolo[2,1-b]quinazoline-6,12-dione
Packaging: 5mg
Price: $398
Updated: 2021/12/16

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8-Nitrotryptanthrin Chemical Properties,Usage,Production

Uses

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

IC 50

rhIDO2: 1.8 μM (IC₅₀); rhIDO2: 0.97 μM (Ki)

References

[1] Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. DOI:10.1016/j.ejmech.2016.07.013
[2] Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. DOI:10.1128/AAC.46.3.882-883.2002
[3] Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67. DOI:10.1021/np3007167

8-Nitrotryptanthrin Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Nitrotryptanthrin

GNF-PF-3777

Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-

GNF-PF-3777 (8-Nitrotryptanthrin)

GNFPF3777,GNF PF 3777,Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO)

8-Nitroindolo[2,1-b]quinazoline-6,12-dione

NF-PF-3777

GNF-PF-3777, 10 mM in DMSO

77603-42-0