NLG919
- Product Name
- NLG919
- CAS No.
- 1402836-58-1
- Chemical Name
- NLG919
- Synonyms
- NLG91;NLG919;CS-820;RG6078;GDC0919;RG 6078;RG-6078;GDC-0919;GDC 0919;NLG919, >=98%
- CBNumber
- CB22665157
- Molecular Formula
- C18H22N2O
- Formula Weight
- 282.38
- MOL File
- 1402836-58-1.mol
NLG919 Property
- Melting point:
- 143 - 146°C
- Boiling point:
- 524.6±33.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 15 mg/ml)
- form
- solid
- pka
- 14.85±0.20(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21509
- Product name
- NLG-919
- Purity
- ≥98% (mixture of enantiomers)
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 21509
- Product name
- NLG-919
- Purity
- ≥98% (mixture of enantiomers)
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 21509
- Product name
- NLG-919
- Purity
- ≥98% (mixture of enantiomers)
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 21509
- Product name
- NLG-919
- Purity
- ≥98% (mixture of enantiomers)
- Packaging
- 25mg
- Price
- $397
- Updated
- 2024/03/01
- Product number
- N630000
- Product name
- NLG919
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
NLG919 Chemical Properties,Usage,Production
Description
(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM). (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.
Uses
NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.
target
IDO pathway
References
1) Mautino?et al.?(2013),?NLG919, a novel indolamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy;?Cancer Res.?73?issue 8 supplement?491 2) Li?et al.?(2014),?The indolamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma;?J. Immunother. Cancer?2?21 3) Meng?et al.?(2017),?Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model;?Int. J. Immunopathol. Pharmacol.?30?215
NLG919 Preparation Products And Raw materials
Raw materials
Preparation Products
NLG919 Suppliers
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- 13621943973
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- China
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- 86-21-57758967
- sales@boylechem.com
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- China
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- 021-021-58432009 400-005-6266
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- 021-58436166
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- China
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- 400-6009262 16621234537
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- 021-64823266
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- China
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- 021-54306202 13764082696;
- info@hanhongsci.com
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- China
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- 027-027-83314682 13554138826
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- +86 (27) 8331-4682
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- China
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- 0411-62910999 13889544652
- sales@meilune.com
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- China
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- 021-58170097
- info@topbiochem.com
- Country
- China
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View Lastest Price from NLG919 manufacturers
- Product
- NLG919 1402836-58-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31
- Product
- NLG919 1402836-58-1
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03