ChemicalBook > CAS DataBase List > NLG919

NLG919

Product Name
NLG919
CAS No.
1402836-58-1
Chemical Name
NLG919
Synonyms
NLG91;NLG919;CS-820;RG6078;GDC0919;RG 6078;RG-6078;GDC-0919;GDC 0919;NLG919, >=98%
CBNumber
CB22665157
Molecular Formula
C18H22N2O
Formula Weight
282.38
MOL File
1402836-58-1.mol
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NLG919 Property

Melting point:
143 - 146°C
Boiling point:
524.6±33.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 15 mg/ml)
form 
solid
pka
14.85±0.20(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21509
Product name
NLG-919
Purity
≥98% (mixture of enantiomers)
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21509
Product name
NLG-919
Purity
≥98% (mixture of enantiomers)
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
21509
Product name
NLG-919
Purity
≥98% (mixture of enantiomers)
Packaging
10mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
21509
Product name
NLG-919
Purity
≥98% (mixture of enantiomers)
Packaging
25mg
Price
$397
Updated
2024/03/01
TRC
Product number
N630000
Product name
NLG919
Packaging
10mg
Price
$150
Updated
2021/12/16
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NLG919 Chemical Properties,Usage,Production

Description

(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM). (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.

Uses

NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.

target

IDO pathway

References

1) Mautino?et al.?(2013),?NLG919, a novel indolamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy;?Cancer Res.?73?issue 8 supplement?491 2) Li?et al.?(2014),?The indolamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma;?J. Immunother. Cancer?2?21 3) Meng?et al.?(2017),?Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model;?Int. J. Immunopathol. Pharmacol.?30?215

NLG919 Preparation Products And Raw materials

Raw materials

Preparation Products

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NLG919 Suppliers

China 158 India 2 United States 16 Global 176
Shanghai JiYi Biotechnology Co. Ltd.
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InvivoChem
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Energy Chemical
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View Lastest Price from NLG919 manufacturers

Career Henan Chemical Co
Product
NLG919 1402836-58-1
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

1402836-58-1, NLG919Related Search:

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  • 5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindole
  • NLG919(GDC-0919,Navoximod)
  • CS-820
  • GDC 0919
  • GDC0919
  • GDC-0919
  • NLG-919; NLG 919; IDO INHIBITOR;GDC-0919;GDC 0919;GDC0919
  • NLG919
  • 1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL
  • 5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-
  • 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol NLG919
  • NLG919 1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL
  • NLG919;NAVOXIMOD
  • NLG919 (GDC-0919)
  • alpha-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol
  • NLG919, >=98%
  • NLG919;NLG-919
  • NLG-919 analogue
  • IDO inhibitor 7
  • 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol
  • NLG919 USP/EP/BP
  • 5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-
  • NLG91
  • RG 6078
  • RG6078
  • RG-6078
  • 1402836-58-1
  • Inhibitor
  • Inhibitors