ChemicalBook > CAS DataBase List > IDO-IN-1

IDO-IN-1

Product Name
IDO-IN-1
CAS No.
914638-30-5
Chemical Name
IDO-IN-1
Synonyms
CS-1532;DO-IN-1;IDO-IN-1;4-amino-N(3-bromo-4-fluorophenyl)-N-hydroxy-;Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO),IDO IN 1,IDOIN1;4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide;4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide;1,2,5-Oxadiazole-3-carboximidamide, 4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-;(E)-4-amino-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;(Z)-4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CBNumber
CB73041412
Molecular Formula
C9H7BrFN5O2
Formula Weight
316.09
MOL File
914638-30-5.mol
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IDO-IN-1 Property

Boiling point:
512.6±60.0 °C(Predicted)
Density 
2.03±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥29.1 mg/mL in DMSO; ≥25.9 mg/mL in EtOH; insoluble in H2O
form 
crystalline solid
pka
7.54±0.69(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19402
Product name
IDO-IN-1
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
19402
Product name
IDO-IN-1
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
19402
Product name
IDO-IN-1
Purity
≥98%
Packaging
10mg
Price
$632
Updated
2024/03/01
ApexBio Technology
Product number
C3211
Product name
IDO-IN-1
Packaging
10mg
Price
$720
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0419840
Product name
(Z)-4-AMINO-N'-(3-BROMO-4-FLUOROPHENYL)-N-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXIMIDAMIDE
Purity
95.00%
Packaging
5MG
Price
$498.54
Updated
2021/12/16
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IDO-IN-1 Chemical Properties,Usage,Production

Biological Activity

ido-in-1 is an indoleamine-2,3-dioxygenase (ido) inhibitor.ido is expressed in various tissues throughout the body but mainly in cells within the immune system where it is induced in dendritic cells and macrophages at sites of inflammation by cytokines. the overexpression of ido has been implicated in a variety of diseases, such as cancer, neurodegenerative disorders, age-related cataract, and hiv encephalitis.

in vitro

in previous study, ido-in-1 was found to have improved in-vitro human intrinsic clearances without loss in ido cellular potency [1].

in vivo

ido-in-1 analog, named 5l, was chosen for further in vivo studies because of its improved physical chemical properties compared to ido-in-1. the efficacy of 5l was tested in c57bl/6 mice with gmcsf-secreting b16 tumors, where 1-mt had previously shown activity. results showed that the dose-dependent inhibition of tumor growth was linked to increasing exposures of 5l in plasma. in addition, a maximal effect of 50% tumor growth control (tgc) was observed when 5l was subcutaneously administered at 75 mg/kg bid. for comparison, 1-mt showed around 45% tgc when administered as subcutaneous pellets [1].

IC 50

59 nm

References

[1] yue ew, et al. discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. j med chem. 2009 dec 10;52(23):7364-7.

IDO-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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IDO-IN-1 Suppliers

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View Lastest Price from IDO-IN-1 manufacturers

Career Henan Chemical Co
Product
IDO-IN-1 914638-30-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-03-13

914638-30-5, IDO-IN-1Related Search:

4-Aminodiphenylamine N-Methylbenzamide 8-Nitrotryptanthrin Β-LAPACHONE IDO-IN-7 indoleaMine-2,3-dioxygenase inhibitor INCB024360 NLG919 IDO-IN-4 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 1-METHYL-D-TRYPTOPHAN IDO-IN-3

  • IDO-IN-1
  • (Z)-4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • (E)-4-amino-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • CS-1532
  • IDO-IN-1/4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • 1,2,5-Oxadiazole-3-carboximidamide, 4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-
  • DO-IN-1
  • 4-amino-N(3-bromo-4-fluorophenyl)-N-hydroxy-
  • Inhibitor,inhibit,Indoleamine 2,3-Dioxygenase (IDO),IDO IN 1,IDOIN1
  • 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • (Z)-4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
  • 914638-30-5
  • C9H7BrFN5O2