3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
- Product Name
- 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
- CAS No.
- 198474-05-4
- Chemical Name
- 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
- Synonyms
- EOS200271;PF-06840003;EOS200271 PF-06840003;PF-06840003 (racemate);PF 06840003;PF-06840003;PF-06840003 (EOS-200271);3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione;2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-
- CBNumber
- CB12523559
- Molecular Formula
- C12H9FN2O2
- Formula Weight
- 232.21
- MOL File
- 198474-05-4.mol
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Property
- Melting point:
- 190-195 °C
- Boiling point:
- 533.2±50.0 °C(Predicted)
- Density
- 1.464±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- form
- solid
- pka
- 9.13±0.50(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25003
- Product name
- EOS200271
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 25003
- Product name
- EOS200271
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2023/01/06
- Product number
- 25003
- Product name
- EOS200271
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 25003
- Product name
- EOS200271
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- P293790
- Product name
- PF-06840003
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Usage,Production
Description
PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Uses
PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.
References
1) Crosignani?et al.?(2017),?Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate;?J. Med. Chem.?60?9617 2) Gomes?et al.?(2018),?Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy;?Mol. Cancer Ther.?9?2530 3) Blair?et al.?(2019),?IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma;?J. Clin. Invest.?129?1742
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials
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View Lastest Price from 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione manufacturers
- Product
- 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 198474-05-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25