ChemicalBook > CAS DataBase List > 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

Product Name
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
CAS No.
198474-05-4
Chemical Name
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
Synonyms
EOS200271;PF-06840003;EOS200271 PF-06840003;PF-06840003 (racemate);PF 06840003;PF-06840003;PF-06840003 (EOS-200271);3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione;3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione;3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione;2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-
CBNumber
CB12523559
Molecular Formula
C12H9FN2O2
Formula Weight
232.21
MOL File
198474-05-4.mol
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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Property

Melting point:
190-195 °C
Boiling point:
533.2±50.0 °C(Predicted)
Density 
1.464±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
form 
solid
pka
9.13±0.50(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25003
Product name
EOS200271
Purity
≥98%
Packaging
5mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
25003
Product name
EOS200271
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2023/01/06
Cayman Chemical
Product number
25003
Product name
EOS200271
Purity
≥98%
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25003
Product name
EOS200271
Purity
≥98%
Packaging
25mg
Price
$90
Updated
2024/03/01
TRC
Product number
P293790
Product name
PF-06840003
Packaging
100mg
Price
$90
Updated
2021/12/16
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3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Usage,Production

Description

PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3

Uses

PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.

References

1) Crosignani?et al.?(2017),?Discovery of a Novel and Selective Indoleamine-2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EROS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate;?J. Med. Chem.?60?9617 2) Gomes?et al.?(2018),?Characterization of the Selective Indoleamine-2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy;?Mol. Cancer Ther.?9?2530 3) Blair?et al.?(2019),?IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma;?J. Clin. Invest.?129?1742

3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione manufacturers

Career Henan Chemical Co
Product
3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 198474-05-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

198474-05-4, 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dioneRelated Search:


  • 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
  • 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
  • PF-06840003
  • 2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-
  • 3-(5-Fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione
  • PF-06840003 (racemate)
  • EOS200271
  • PF 06840003;PF-06840003
  • EOS200271 PF-06840003
  • PF-06840003 (EOS-200271)
  • 198474-05-4
  • API