ChemicalBook > CAS DataBase List > PF 573228

PF 573228

Product Name
PF 573228
CAS No.
869288-64-2
Chemical Name
PF 573228
Synonyms
PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228 DISCONTINUED;PF-573228, 10 mM in DMSO;Focal Adhesion Kinase Inhibitor II;PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II
CBNumber
CB42459138
Molecular Formula
C22H20F3N5O3S
Formula Weight
491.49
MOL File
869288-64-2.mol
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PF 573228 Property

Melting point:
>242°C (dec.)
Density 
1.459
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
14.30±0.20(Predicted)
color 
white to off-white
InChIKey
HESLKTSGTIBHJU-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0117
Product name
PF-573228
Purity
≥95% (HPLC)
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
324878
Product name
Focal Adhesion Kinase Inhibitor II
Packaging
10mg
Price
$233
Updated
2022/05/15
Cayman Chemical
Product number
14924
Product name
PF-573228
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14924
Product name
PF-573228
Purity
≥95%
Packaging
5mg
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0117
Product name
PF-573228
Purity
≥95% (HPLC)
Packaging
25mg
Price
$576
Updated
2024/03/01
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PF 573228 Chemical Properties,Usage,Production

Description

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

Uses

A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.

Definition

ChEBI: 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3,4-dihydro-1H-quinolin-2-one is a member of quinolines.

Biochem/physiol Actions

PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.

storage

Store at +4°C

References

[1]. slack-davis, j.k., et al., cellular characterization of a novel focal adhesion kinase inhibitor. j biol chem, 2007. 282(20): p. 14845-52.
[2]. golubovskaya, v.m., focal adhesion kinase as a cancer therapy target. anticancer agents med chem, 2010. 10(10): p. 735-41.
[3]. cabrita, m.a., et al., focal adhesion kinase inhibitors are potent anti-angiogenic agents. mol oncol, 2011. 5(6): p. 517-26.
[4]. al-toub, m., et al., pleiotropic effects of cancer cells' secreted factors on human stromal (mesenchymal) stem cells. stem cell res ther, 2013. 4(5): p. 114.
[5]. so, e.c., et al., evidence for activation of bk ca channels by a known inhibitor of focal adhesion kinase, pf573228. life sci, 2011. 89(19-20): p. 691-701.

PF 573228 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 573228 Suppliers

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View Lastest Price from PF 573228 manufacturers

Career Henan Chemical Co
Product
PF 573228;3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone 869288-64-2
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

869288-64-2, PF 573228Related Search:

PF-3450074 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester PF-9366 PI-3065 Everolimus MK-2206 2HCl PF-562271 Dasatinib Vorinostat PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF-3758309

  • PF 573228
  • 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
  • 6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one
  • CS-253
  • Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
  • 6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one
  • 2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
  • Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228
  • PF 573228 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one
  • PF-228
  • PF-573228, >=98%
  • PF-573228;PF 573228
  • 3,4-DIHYDRO-6-[[4-[[[3-(METHYLSULFONYL)PHENYL]METHYL]AMINO]-5-(TRIFLUOROMETHYL)-PYRIMIDIN-2-YL]AMINO]-2(1H)-QUINOLINONE
  • 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]
  • Focal Adhesion Kinase Inhibitor II
  • 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one
  • PF 573228 USP/EP/BP
  • PF-573228 DISCONTINUED
  • PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II
  • PF-573228, 10 mM in DMSO
  • 869288-64-2
  • C22H20F3N5O3S
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
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