PI-3065
- Product Name
- PI-3065
- CAS No.
- 955977-50-1
- Chemical Name
- PI-3065
- Synonyms
- 129556;PI-306;PI-3065;CS-1274;PI-3065, >=98%;PI-3065|PI3065;PI-3065 USP/EP/BP;4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
- CBNumber
- CB02705093
- Molecular Formula
- C27H31FN6OS
- Formula Weight
- 506.64
- MOL File
- 955977-50-1.mol
PI-3065 Property
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 14.80±0.30(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 955977-50-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9002394
- Product name
- PI-3065
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 9002394
- Product name
- PI-3065
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 9002394
- Product name
- PI-3065
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 9002394
- Product name
- PI-3065
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- 5919
- Product name
- PI3065
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1045
- Updated
- 2021/12/16
PI-3065 Chemical Properties,Usage,Production
Biological Activity
pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].
in vitro
PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.
target
| p110α 910 nM (IC 50 ) | p110β 600 nM (IC 50 ) | p110δ 5 nM (IC 50 ) |
storage
Store at -20°C
PI-3065 Preparation Products And Raw materials
Raw materials
Preparation Products
PI-3065 Suppliers
- Tel
- 0512-0512-13601744364 13601744364
- chemsharker@126.com
- Country
- China
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- 86-21-57758967
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- China
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- 21-57721279
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- QQ：14057904
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- China
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- 0510-83588313-802 18800520310;
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- China
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- 0411-62910999 13889544652
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- Country
- China
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- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
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- 021-58170097
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- China
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- (86) 21-58955996
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- Mobile:13665161512
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- +86-510-68873513
- Country
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- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 7295
- Advantage
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View Lastest Price from PI-3065 manufacturers
- Product
- PI-3065 955977-50-1
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20