ChemicalBook > CAS DataBase List > PI-3065

PI-3065

Product Name
PI-3065
CAS No.
955977-50-1
Chemical Name
PI-3065
Synonyms
129556;PI-306;PI-3065;CS-1274;PI-3065, >=98%;PI-3065|PI3065;PI-3065 USP/EP/BP;4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
CBNumber
CB02705093
Molecular Formula
C27H31FN6OS
Formula Weight
506.64
MOL File
955977-50-1.mol
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PI-3065 Property

Density 
1.372±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
14.80±0.30(Predicted)
CAS DataBase Reference
955977-50-1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9002394
Product name
PI-3065
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9002394
Product name
PI-3065
Purity
≥98%
Packaging
5mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
9002394
Product name
PI-3065
Purity
≥98%
Packaging
10mg
Price
$274
Updated
2024/03/01
Cayman Chemical
Product number
9002394
Product name
PI-3065
Purity
≥98%
Packaging
25mg
Price
$553
Updated
2024/03/01
Tocris
Product number
5919
Product name
PI3065
Purity
≥98%(HPLC)
Packaging
50
Price
$1045
Updated
2021/12/16
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PI-3065 Chemical Properties,Usage,Production

Biological Activity

pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].

in vitro

PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.

target

p110α

910 nM (IC 50 )

p110β

600 nM (IC 50 )

p110δ

5 nM (IC 50 )

storage

Store at -20°C

PI-3065 Preparation Products And Raw materials

Raw materials

Preparation Products

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PI-3065 Suppliers

China 74 India 1 United Kingdom 1 United States 12 Global 88
Shanghai Dongyang Biotechnology Co., Ltd.
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View Lastest Price from PI-3065 manufacturers

Career Henan Chemical Co
Product
PI-3065 955977-50-1
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

955977-50-1, PI-3065Related Search:

PFI-2 (hydrochloride) PF-3450074 PF-562271 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester PF 573228 PF-9366 Sorafenib tosylate HS-173 Anastrozole LDN-193189 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Doxorubicin hydrochloride

  • PI-3065
  • 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine
  • PI-3065|PI3065
  • 4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine
  • 6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine
  • 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065
  • PI-3065, >=98%
  • 129556
  • Thieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-
  • CS-1274
  • 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
  • PI-306
  • 4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri
  • PI-3065 USP/EP/BP
  • 955977-50-1
  • C27H31FN6OS
  • Inhibitors