HS-173
- Product Name
- HS-173
- CAS No.
- 1276110-06-5
- Chemical Name
- HS-173
- Synonyms
- HS-173;CS-1007;HS 173;HS173;HS-173 USP/EP/BP;PI3K Inhibitor HS-173 HS173;HS-173, 98%, a novel PI3K inhibitor;PI3K,Apoptosis,Phosphoinositide 3-kinase,HS-173,Inhibitor,inhibit;ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-, ethyl ester
- CBNumber
- CB52708130
- Molecular Formula
- C21H18N4O4S
- Formula Weight
- 422.46
- MOL File
- 1276110-06-5.mol
HS-173 Property
- Melting point:
- >193°C (dec.)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 6.84±0.40(Predicted)
- form
- Solid
- color
- Grey to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5.32384
- Product name
- PI3K Inhibitor, HS-173 - Calbiochem
- Purity
- PI3 K alpha inhibitor; anti-fibrolytic agent; HS-173
- Packaging
- 10MG
- Price
- $196
- Updated
- 2024/03/01
- Product number
- 19156
- Product name
- HS-173
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19156
- Product name
- HS-173
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 19156
- Product name
- HS-173
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 19156
- Product name
- HS-173
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $397
- Updated
- 2024/03/01
HS-173 Chemical Properties,Usage,Production
Description
HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM. It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively. HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases. It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.
Uses
HS-173 is a potent PI3Kα inhibitor with anticancer activity.
in vitro
hs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1].
in vivo
hs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1].
target
PI3Kα
References
[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9.
HS-173 Preparation Products And Raw materials
Raw materials
Preparation Products
HS-173 Suppliers
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View Lastest Price from HS-173 manufacturers
- Product
- HS-173 1276110-06-5
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23