HS-173

ChemicalBook > CAS DataBase List > HS-173

Product Name: HS-173
CAS No.: 1276110-06-5
Chemical Name: HS-173
Synonyms: HS-173;CS-1007;HS 173;HS173;HS-173 USP/EP/BP;PI3K Inhibitor HS-173 HS173;HS-173, 98%, a novel PI3K inhibitor;PI3K,Apoptosis,Phosphoinositide 3-kinase,HS-173,Inhibitor,inhibit;ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate;6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-, ethyl ester
CBNumber: CB52708130
Molecular Formula: C21H18N4O4S
Formula Weight: 422.46
MOL File: 1276110-06-5.mol

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HS-173 Property

Melting point:: >193°C (dec.)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
pka: 6.84±0.40(Predicted)
form: Solid
color: Grey to Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.32384
Product name: PI3K Inhibitor, HS-173 - Calbiochem
Purity: PI3 K alpha inhibitor; anti-fibrolytic agent; HS-173
Packaging: 10MG
Price: $196
Updated: 2024/03/01

Cayman Chemical

Product number: 19156
Product name: HS-173
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19156
Product name: HS-173
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 19156
Product name: HS-173
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 19156
Product name: HS-173
Purity: ≥98%
Packaging: 25mg
Price: $397
Updated: 2024/03/01

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HS-173 Chemical Properties,Usage,Production

Description

HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC₅₀ value of 0.8 nM. It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC₅₀ values of 0.6, 1.5, and 7.8 μM, respectively. HS-173 is reported to induce apoptosis by arresting the cell cycle at the G₂/M phase and by activating caspases. It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.

Uses

HS-173 is a potent PI3Kα inhibitor with anticancer activity.

in vitro

hs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1].

in vivo

hs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1].

target

PI3Kα

References

[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9.

HS-173 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HS-173 manufacturers

Career Henan Chemical Co

Product: HS-173 1276110-06-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1276110-06-5, HS-173Related Search:

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HS 173;HS173

CS-1007

ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate

6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester HS-173

HS-173

6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

HS-173, 98%, a novel PI3K inhibitor

Imidazo[1,2-a]pyridine-3-carboxylic acid, 6-[5-[(phenylsulfonyl)amino]-3-pyridinyl]-, ethyl ester

HS-173 USP/EP/BP

PI3K Inhibitor HS-173 HS173

PI3K,Apoptosis,Phosphoinositide 3-kinase,HS-173,Inhibitor,inhibit

1276110-06-5

Inhibitors