5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Product Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS No.: 1134156-31-2
Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Synonyms: CS-1647;VER 155088;VER 155008;HSP70 inhibitor;VER-155008, ≥98% (HPLC);VER 155008;VER-155008;VER155008;8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine;8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008;5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine;5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CBNumber: CB22518790
Molecular Formula: C25H23Cl2N7O4
Formula Weight: 556.4
MOL File: 1134156-31-2.mol

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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Property

Boiling point:: 856.3±75.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: 13.04±0.70(Predicted)
form: powder
color: white to light brown
InChIKey: ZXGGCBQORXDVTE-UMCMBGNQSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0271
Product name: VER-155008
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0271
Product name: VER-155008
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $531
Updated: 2024/03/01

Cayman Chemical

Product number: 17257
Product name: VER-155008
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17257
Product name: VER-155008
Purity: ≥95%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 17257
Product name: VER-155008
Purity: ≥95%
Packaging: 25mg
Price: $388
Updated: 2024/03/01

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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Chemical Properties,Usage,Production

Uses

VER 155008 is a novel adenosine-derived inhibitor of heat-shocked protein 70, Hsp70 resulting in an inhibition of cell proliferation of human cancer cell lines.

Uses

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:

to study its effects on human embryonic kidney 293 (HEK293T)?cells
to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
to determine its effects on the attenuation of seizures in rats

Definition

ChEBI: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]-9-purinyl]-3,4-dihydroxy-2-oxolanyl]methoxymethyl]benzonitrile is a purine nucleoside.

Biological Activity

ver 155008 is a potent inhibitor of heat shock protein 70 (hsp70) family of chaperones, which have been shown to contribute to cancer cell survival via anti-apoptotic functions, that inhibits hsp70 (with the value of 50% inhibition concentration ic50 of 0.5 μm) as well as heat shock cognate 71 kda protein (hsc70) and 78 kda glucose-regulated protein (grp78) but to a lesser extent. x-ray crystallography analysis reveals that ver 155008 binds to the atpase pocket of hsp70 leading to the inhibition of the intrinsic atpase activity of hsp70. study results also have demonstrated that ver 155008 induces cell proliferation and apoptosis in human cancer cell lines.massey aj, williamson ds, browne h, murray jb, dokurno p, shaw t, macias at, daniels z, geoffroy s, dopson m, lavan p, matassova n, francis gl, graham cj, parsons r, wang y, padfield a, comer m, drysdale mj, wood m. a novel, small molecule inhibitor of hsc70/hsp70 potentiates hsp90 inhibitor induced apoptosis in hct116 colon carcinoma cells. cancer chemother pharmacol. 2010; 66(3): 535-545

Biochem/physiol Actions

VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

storage

Desiccate at RT

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Suppliers

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View Lastest Price from 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine manufacturers

Career Henan Chemical Co

Product: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine 1134156-31-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-22

1134156-31-2, 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosineRelated Search:

VER-246608 VER-50589 VER-49009

VER 155008

4-((((2R,3S,4R,5R)-5-(6-aMino-8-((3,4-dichlorobenzyl)aMino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)benzonitrile

8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine

4-{(2R,3S,4R,5R)-5-[6-aMino-8-(3,4-dichlorobenzylaMino)purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-ylMethoxyMethyl}benzonitrile

VER 155088

CS-1647

VER 155008;VER-155008;VER155008

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

HSP70 inhibitor

Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-

8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008

VER-155008, ≥98% (HPLC)

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

1134156-31-2

C25H23Cl2N7O4