VER-49009
- Product Name
- VER-49009
- CAS No.
- 558640-51-0
- Chemical Name
- VER-49009
- Synonyms
- CS-2575;CCT 129397;VER-49009（b;VER-49009;VER 49009;VER49009;5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-;VER-49009,Inhibitor,CCT-129397,CCT129397,HSP,inhibit,VER 49009,Heat shock proteins,VER49009
- CBNumber
- CB22705097
- Molecular Formula
- C19H18ClN3O4
- Formula Weight
- 387.82
- MOL File
- 558640-51-0.mol
VER-49009 Property
- Boiling point:
- 620.2±55.0 °C(Predicted)
- Density
- 1.379±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (257.85 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 7.86±0.25(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13131
- Product name
- VER-49009
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 13131
- Product name
- VER-49009
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 13131
- Product name
- VER-49009
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $796
- Updated
- 2024/03/01
- Product number
- 13131
- Product name
- VER-49009
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $1394
- Updated
- 2024/03/01
- Product number
- V756800
- Product name
- VER49009
- Packaging
- 10mg
- Price
- $1485
- Updated
- 2021/12/16
VER-49009 Chemical Properties,Usage,Production
Uses
VER 49009 is a heat shock protein 90 (HSP90) inhibitor. VER 49009 causes induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5.
Definition
ChEBI: 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)pyrazole-3-carboxamide is an aromatic amide obtained by formal condensation of the carboxy group of 5-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)pyrazole-3-carboxylic acid with the amino group of ethylamine. It has a role as a Hsp90 inhibitor. It is a member of pyrazoles, a member of resorcinols, a member of monochlorobenzenes, a monomethoxybenzene and an aromatic amide.
in vivo
VER-49009 (4 mg/kg, i.p.) results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors[2].
IC 50
HSP90: 25 nM (IC50)
VER-49009 Preparation Products And Raw materials
Raw materials
Preparation Products
VER-49009 Suppliers
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