ChemicalBook > CAS DataBase List > 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Product Name
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
CAS No.
64232-83-3
Chemical Name
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Synonyms
L189;L 189;L189;L189, 10 mM in DMSO;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
CBNumber
CB22518932
Molecular Formula
C11H10N4OS
Formula Weight
246.29
MOL File
64232-83-3.mol
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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Property

Melting point:
250 °C (decomp)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
8.16±0.60(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18374
Product name
L189
Purity
≥95%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
18374
Product name
L189
Purity
≥95%
Packaging
10mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
18374
Product name
L189
Purity
≥95%
Packaging
25mg
Price
$379
Updated
2024/03/01
Cayman Chemical
Product number
18374
Product name
L189
Purity
≥95%
Packaging
50mg
Price
$546
Updated
2024/03/01
Tocris
Product number
3561
Product name
L189
Packaging
10
Price
$181
Updated
2021/12/16
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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Chemical Properties,Usage,Production

Description

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 μM, respectively). It blocks DNA binding (Ki = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

Uses

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

storage

Store at -20°C

References

[1]. xi chen, shijun zhong, xiao zhu, et al. rational design of human dna ligase inhibitors that target cellular dna replication and repair. cancer res., 2008, 68(9): 3169-3177.
[2]. mark r. taylor, john a. conrad, daniel wahl, et al. kinetic mechanism of human dna ligase i reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency. journal of biological chemistry, 2011, 286(26): 23054-23062.
[3]. christian jekimovs, emma bolderson, amila suraweera, et al. chemotherapeutic compounds targeting the dna double-strand break repair pathways: the good, the bad, and the promising. frontiers in oncology, 2014, 4: article 86.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Suppliers

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64232-83-3, 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineoneRelated Search:


  • L 189;L189
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
  • L189
  • 4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
  • (E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
  • 6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • L189, 10 mM in DMSO
  • 64232-83-3