AT7867

ChemicalBook > CAS DataBase List > AT7867

Product Name: AT7867
CAS No.: 857531-00-1
Chemical Name: AT7867
Synonyms: AT7867;CS-1865;AT-7867(AT7867);AT7867 USP/EP/BP;4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine AT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]- 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
CBNumber: CB22526153
Molecular Formula: C20H20ClN3
Formula Weight: 337.85
MOL File: 857531-00-1.mol

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AT7867 Property

Density: 1.214
storage temp.: Store at -20°C
solubility: ≥16.9 mg/mL in DMSO; ≥4.38 mg/mL in EtOH with ultrasonic; ≥45 mg/mL in H2O
form: solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16848
Product name: AT7867
Purity: ≥98%
Packaging: 25mg
Price: $414
Updated: 2024/03/01

Cayman Chemical

Product number: 16848
Product name: AT7867
Purity: ≥98%
Packaging: 500μg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 16848
Product name: AT7867
Purity: ≥98%
Packaging: 1mg
Price: $45
Updated: 2021/12/16

Cayman Chemical

Product number: 16848
Product name: AT7867
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 16848
Product name: AT7867
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

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AT7867 Chemical Properties,Usage,Production

Description

AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC₅₀s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC₅₀s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.

Uses

A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.

Definition

ChEBI: AT7867 is a member of the class of piperidines carrying two aryl substituents (4-chlorophenyl and 4-(pyrazol-4-yl)phenyl) at position 4. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of piperidines and a member of monochlorobenzenes.

Enzyme inhibitor

This potent ATP-competitive inhibitor (FW = 337.85; CAS 857531-00-1; Solubility: 68 mg/mL DMSO, <1 mg/mL H2O), known systematically as 4- (4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine, targets Akt1, Akt2 and Akt3 Protein Kinases B (or PKB), with IC50 values of 32 nM, 17 nM and 47 nM, respectively. AT7867 also inhibits the structurally related AGC kinases, p70S6K and PKA, with IC50 values of 20 nM and 85 nM, respectively.

target

Akt2

References

grimshaw km, hunter lj, yap ta et al. at7867 is a potent and oral inhibitor of akt and p70 s6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. mol cancer ther. 2010 may;9(5):1100-10.

AT7867 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AT7867 manufacturers

Career Henan Chemical Co

Product: AT7867 857531-00-1
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

857531-00-1, AT7867Related Search:

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AT7867

Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-

4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

AT-7867(AT7867)

4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine

4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine AT 7867

CS-1865

Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]- 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

AT7867 USP/EP/BP

857531-00-1

Akt

mTOR

PI3K

Inhibitors