AZD5363

Product Name: AZD5363
CAS No.: 1143532-39-1
Chemical Name: AZD5363
Synonyms: Capivasertib;4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-;CS-561;AZD5636;AZD5363;AZD5356;AZD5363 USP/EP/BP;AZD-5363; AZD 5363;AZD5363(Capivasertib);CAPIVASERTIB (AZD5363)
CBNumber: CB12650349
Molecular Formula: C21H25ClN6O2
Formula Weight: 428.92
MOL File: 1143532-39-1.mol

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AZD5363 Property

Melting point:: 161-164°C
Density: 1.381
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.93±0.50(Predicted)
form: Solid
color: Off-White to Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15406
Product name: AZD 5363
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 15406
Product name: AZD 5363
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 15406
Product name: AZD 5363
Purity: ≥98%
Packaging: 10mg
Price: $231
Updated: 2024/03/01

Cayman Chemical

Product number: 15406
Product name: AZD 5363
Purity: ≥98%
Packaging: 25mg
Price: $412
Updated: 2024/03/01

Tocris

Product number: 6978
Product name: AZD5363
Purity: ≥98%(HPLC)
Packaging: 25
Price: $545
Updated: 2021/12/16

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AZD5363 Chemical Properties,Usage,Production

Uses

AZD5363 is used in inhibiting the proliferation of certain tumor cell lines.

Biological Activity

azd5363 is a novel, potent phosphoinositide 3-kinase (pi3k)/akt pathway inhibitor with ic50 value of ~200nm. [1]azd5363 is proved to inhibit castrate resistant prostate cancer (crpc) progression. clusterin (clu) and autophagy will be induced which may work as cytoprotective responses which can affect the downstream pi3k/akt signaling. [2] azd5363 inhibits the growth of a lot of human tumor cells in a dose dependent manner. the mode of action could be monotherapy as well as in combination with her2 inhibitors in breast cancer models. [3] it is suggested to induce cell apoptosis by measuring the expression of parp cleavage, the activity of caspase 3, et al. [1]most importantly, azd5363 can target the pi3k/akt-pathway in vivo significantly, thus reducing the serum psa-levels and tumor volume, finally, it could postpone the progression to crpc.[1]

target

Akt

storage

Store at -20°C

References

[1] thomas c, crafter c, davies b, zoubeidi a, gleave me. azd5363, a novel akt inhibitor, delays prostate cancer progression. the journal of urology. may 2011. 185(4s): e292-293.
[2] kumano m, zhang f, shiota m, crafter c, davies b, zoubeidi a, gleave m. clusterin knockdown enhances antitumor activity of a novel akt inhibitor, azd5363, through inhibition of autophagy in prostate cancer. the journal of urology. may 21 2012. e392.
[3] davies br, greenwood h, dudley p, et al. preclinical pharmacology of azd5363, an inhibitor of akt: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. mol. cancer ther. arp 2012. 11: 873.

AZD5363 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD5363 Suppliers

China 138 India 2 United States 19 Global 159

Xuzhou Maikai Biotechnology Co., Ltd.

Tel: 13921770081
Email: SVP01@magicbiotech.cn
Country: China
ProdList: 383
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 429
Advantage: 55

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 9958
Advantage: 58

Arizest(Shanghai)Pharmatech Co.,Ltd

Tel: 13671599112
Email: geshi.zhuang@synovent.cn
Country: China
ProdList: 227
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 982
Advantage: 56

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 905
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

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View Lastest Price from AZD5363 manufacturers

Career Henan Chemical Co

Product: AZD5363 1143532-39-1
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

1143532-39-1, AZD5363Related Search:

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AZD5356

AZD5363

4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide

4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-

4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide AZD5363

AZD 5363 dihydrochloride

AZD5363;AZD-5363;AZD 5363

(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidi

Capivasertib

AZD5363, 99%, a potent pan-AKT kinase inhibitor

AZD5636

AZD5363(Capivasertib)

CAPIVASERTIB (AZD5363)

CS-561

AZD-5363; AZD 5363

4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

AZD5363 USP/EP/BP

(S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Capivasertib AZD5363 AZD-5363

Autophagy,AZD 5363,Inhibitor,inhibit,AZD-5363,PKB,Akt,Capivasertib,Protein kinase B

1143532-39-1

C21H25ClN6O2

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR