CX-3543

Product Name: CX-3543
CAS No.: 865311-47-3
Chemical Name: CX-3543
Synonyms: CX-3543;Quarfloxin;Quarfloxacin;Itarnafloxin;CX-3543/Quarfloxin;Quarfloxin (CX-3543);Quarfloxin, 10 mM in DMSO;CX 3543; QUARFLOXACIN; CX3543; CX-3543;inhibit,CX3543,Inhibitor,Quarfloxin,CX 3543,DNA/RNA Synthesis;2-(4-((R)-1-Methylpyrrolidin-2-yl)butanoyl)-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one
CBNumber: CB22526229
Molecular Formula: C35H33FN6O3
Formula Weight: 604.67
MOL File: 865311-47-3.mol

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CX-3543 Property

Boiling point:: 845.3±65.0 °C(Predicted)
Density: 1.44
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 11.46±0.20(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005293
Product name: QUARFLOXIN
Purity: 95.00%
Packaging: 5MG
Price: $499.47
Updated: 2021/12/16

ChemScene

Product number: CS-0003553
Product name: Quarfloxin
Purity: 99.95%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb612000
Product name: Quarfloxin (CX-3543)
Purity: >98%
Packaging: 10mg
Price: $912.9
Updated: 2021/12/16

ChemScene

Product number: CS-0003553
Product name: Quarfloxin
Purity: 99.95%
Packaging: 50mg
Price: $1000
Updated: 2021/12/16

ChemScene

Product number: CS-0003553
Product name: Quarfloxin
Purity: 99.95%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

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CX-3543 Chemical Properties,Usage,Production

Uses

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1].

Definition

ChEBI: Itarnafloxin is a phenoxazine.

References

[1] Hald ?H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12. DOI:10.1038/s41388-018-0611-7

CX-3543 Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-3543 Suppliers

China 29 United States 3 Global 32

shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
Email: sales@cooperpharm.com
Country: China
ProdList: 1210
Advantage: 56

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

865311-47-3, CX-3543Related Search:

CX-3543

2-(4-((R)-1-Methylpyrrolidin-2-yl)butanoyl)-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one

5-Fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Itarnafloxin

Quarfloxacin

Quarfloxin (CX-3543)

Quarfloxin

CX 3543; QUARFLOXACIN; CX3543; CX-3543

3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-

inhibit,CX3543,Inhibitor,Quarfloxin,CX 3543,DNA/RNA Synthesis

CX-3543/Quarfloxin

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

15-fluoro-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-18-oxo-14-[3-(pyrazin-2-yl)pyrrolidin-1-yl]-12-oxa-1-azapentacyclo[11.7.1.02,11.0?,?.01?,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxamide

Quarfloxin, 10 mM in DMSO

865311-47-3

C35H33FN6O3