6-Chloro-3-Methylpyridine-2-carboxylic Acid
- Product Name
- 6-Chloro-3-Methylpyridine-2-carboxylic Acid
- CAS No.
- 1201924-32-4
- Chemical Name
- 6-Chloro-3-Methylpyridine-2-carboxylic Acid
- Synonyms
- 6-chloro-3-methylpyridine-2-carboxylicaci;6-Chloro-3-methyl-pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-chloro-3-methyl-
- CBNumber
- CB22535225
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 1201924-32-4.mol
6-Chloro-3-Methylpyridine-2-carboxylic Acid Property
- Boiling point:
- 333.7±37.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.93±0.32(Predicted)
- Appearance
- White to off-white Solid
Safety
- WGK Germany
- 3
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C369520
- Product name
- 6-Chloro-3-methylpyridine-2-carboxylicAcid
- Packaging
- 2.5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- X7045
- Product name
- 6-Chloro-3-methylpicolinic acid
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- X7045
- Product name
- 6-Chloro-3-methylpicolinic acid
- Packaging
- 25g
- Price
- $1011
- Updated
- 2021/12/16
- Product number
- OR926007
- Product name
- 6-Chloro-3-methylpicolinic acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- X7045
- Product name
- 6-Chloro-3-methylpicolinic acid
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
6-Chloro-3-Methylpyridine-2-carboxylic Acid Chemical Properties,Usage,Production
Uses
6-Chloro-3-methylpyridine-2-carboxylic Acid is disubstituted pyridinecarboxylic acid used in the preparation of biologically active compounds such as inhibitors of Janus kinases and PDK1.
Synthesis
878207-92-2
1201924-32-4
An aqueous 2N NaOH solution (5 mL) was slowly added dropwise to a stirred solution of methyl 6-chloro-3-methylpyridine-2-carboxylate (0.500 g, 2.702 mmol) in tetrahydrofuran (THF, 10 mL) at 0 °C. The reaction mixture was then warmed to 50 °C with continuous stirring for 2 hours. Upon completion of the reaction, the mixture was acidified to pH < 7 with aqueous citric acid and subsequently extracted with ethyl acetate (EtOAc, 2 × 10 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-chloro-3-methylpyridine-2-carboxylic acid as an off-white solid (0.45 g, 97% yield). The resulting product could be used in the subsequent reaction without further purification. Mass spectrometry (MS) analysis showed the molecular ion peak (m/z) of the target compound: 172.0 ([M+H]+).
References
[1] Patent: WO2015/94912, 2015, A1. Location in patent: Page/Page column 12
[2] Patent: WO2014/4230, 2014, A1. Location in patent: Page/Page column 8; 45
6-Chloro-3-Methylpyridine-2-carboxylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-3-Methylpyridine-2-carboxylic Acid manufacturers
- Product
- 6-Chloro-3-Methylpyridine-2-carboxylic Acid 1201924-32-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27
- Product
- 6-Chloro-3-Methylpyridine-2-carboxylic Acid 1201924-32-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-27
- Product
- 6-Chloro-3-Methylpyridine-2-carboxylic Acid 1201924-32-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-24