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PF 184

Product Name
PF 184
CAS No.
1187460-81-6
Chemical Name
PF 184
Synonyms
PF 184;8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide;1H-Benz[g]indazole-3-carboxamide, 8-[[[2-[3,4-bis(hydroxymethyl)-3,4-dimethyl-1-pyrrolidinyl]-5-chloro-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
CBNumber
CB22535689
Molecular Formula
C32H32ClFN6O4
Formula Weight
619.09
MOL File
1187460-81-6.mol
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PF 184 Property

Boiling point:
790.6±60.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO
form 
Powder
pka
10.20±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4238
Product name
PF184
Purity
≥98%(HPLC)
Packaging
10
Price
$331
Updated
2021/12/16
TRC
Product number
P293750
Product name
PF184
Packaging
1mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
019312
Product name
PF 184
Packaging
10mg
Price
$502
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010308
Product name
8-[[[5-CHLORO-2-[3,4-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-1-PYRROLIDINYL]-4-PYRIDINYL]CARBONYL]AMINO]-1-(4-FLUOROPHENYL)-4,5-DIHYDRO-1H-BENZ[G]INDAZOLE-3-CARBOXAMIDE
Purity
95.00%
Packaging
10MG
Price
$716.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010308
Product name
8-[[[5-CHLORO-2-[3,4-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-1-PYRROLIDINYL]-4-PYRIDINYL]CARBONYL]AMINO]-1-(4-FLUOROPHENYL)-4,5-DIHYDRO-1H-BENZ[G]INDAZOLE-3-CARBOXAMIDE
Purity
95.00%
Packaging
25MG
Price
$779.63
Updated
2021/12/16
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PF 184 Chemical Properties,Usage,Production

Uses

PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.

in vivo

(Rac)-PF-184 (0.3-2.5 mg; i.t.; once) blocks neutrophil infiltration and BAL cell cytokine production[1].

Animal Model:Fasted male Sprague-Dawley rats (350 g) placed into a chamber connected to a large volume nebulizer filled with 20 ml of 1 mg/mL solution of LPS[1]
Dosage:0.3-2.5 mg
Administration:Nano suspension and administered intratracheally in a volume of 100 μL, 60 min before aerosolized LPS
Result:Resulted in a comparable attenuation of total cell and PMN cell infiltration 4 h after LPS exposure. Dose-dependently inhibited cell infiltration with EC50 values of 1 mg. Dose-dependently suppressed BAL fluid TNF- and PGE2 levels comparable with cell infiltration. Inhibited p65 translocation. Showed long-lasting activity.

IC 50

IKK-2: 37 nM (IC50)

storage

Store at +4°C

PF 184 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 184 Suppliers

Canada 1 China 24 India 1 United Kingdom 1 United States 7 Global 34
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24964
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5975
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58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58

1187460-81-6, PF 184Related Search:


  • PF 184
  • 8-[[[5-Chloro-2-[3,4-diMethyl-3,4-bis(hydroxyMethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]aMino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxaMide
  • 1H-Benz[g]indazole-3-carboxamide, 8-[[[2-[3,4-bis(hydroxymethyl)-3,4-dimethyl-1-pyrrolidinyl]-5-chloro-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
  • 1187460-81-6
  • C32H32ClFN6O4
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals