ChemicalBook > CAS DataBase List > 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

Product Name
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
CAS No.
666816-98-4
Chemical Name
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
Synonyms
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine;8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione;8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;Linagliptin INT1;8-BROMO-7-(BUT-2-YNYL);Linagliptin Impurity 36;Linagliptin Impurity 73;Iinagliptin Intermediate2;Linagliptin interMediateC
CBNumber
CB22538943
Molecular Formula
C10H9BrN4O2
Formula Weight
297.11
MOL File
666816-98-4.mol
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8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Property

Melting point:
285 °C
Density 
1.71
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder to crystal
pka
8.91±0.70(Predicted)
color 
White to Almost white
LogP
1.25 at 20℃
CAS DataBase Reference
666816-98-4
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4454
Product name
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$103
Updated
2024/03/01
TCI Chemical
Product number
B4454
Product name
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$334
Updated
2023/01/07
TRC
Product number
B687605
Product name
8-Bromo-3-methyl-7-(2-butynyl)-xanthine
Packaging
100mg
Price
$65
Updated
2021/12/16
Chem-Impex
Product number
43531
Product name
8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
200MG
Price
$107.46
Updated
2021/12/16
Matrix Scientific
Product number
096910
Product name
8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
Purity
95+%
Packaging
1g
Price
$19
Updated
2021/12/16
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8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol), Sodium carbonate (1.590 g, 15 mmol), and 20mL of acetone was added to a 100mL flask. The reaction system was heated to 40 ° C, and the reaction was stirred for 4h. After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid. The crude product was reconstituted with dichloromethane and cyclohexane. Yield 2.912 g of 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione. The yield was 98%, and the purity was 99.9%.

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione Suppliers

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View Lastest Price from 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione 666816-98-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
hundreds of kgs
Release date
2022-02-17
Nanjing Fred Technology Co., Ltd
Product
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 666816-98-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-03
PNP Biotech Co. Ltd
Product
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 666816-98-4
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-10-19

666816-98-4, 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dioneRelated Search:

Linagliptin impurity 15 (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester Canagliflozin Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Rivaroxaban 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid Linagliptin 5-Acetyl Rhein 1,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol Palonosetron Impurity 11 Clavulanate Potassium Impurity 12 DiHCl(Clavulanate Potassium EP Impurity M DiHCl) ZMZPVNYRPCNJGC-UHFFFAOYSA-N Pitavastatin Defuoro IMpurity CalciuM Salt 9-Piperazino Ofloxacin Chlorhexidine Diacetate Donepezil

  • 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
  • 8-broMo-7-(but-2-ynyl)-3-Methyl-3,7-dihydropurine-2,6-dione
  • 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
  • 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
  • 8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione
  • 8-broMo-7-but-2-yn-1-yl-3-Methyl-3,7-dihydro-1H-purine-2,6-dione
  • 8-BroMo-7-(2-butyn-a-yl)-3,7-dihydro-3-Methyl-1-1H-purine-2,6-dione
  • Linagliptin interMediateC
  • (R)-tert-butyl 1-(7-(but-2-ynyl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-ylcarbaMate
  • 3-Methyl-7-(2-butin-1-yl)-8-broMoxanthine
  • 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine
  • 1H-Purine-2,6-dione, 8-broMo-7-(2-butynyl)-3,7-dihydro-3-Methyl-
  • 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H
  • 8- bromo -7-(2- butyne)-3- methyl xanthine
  • 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2
  • 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-indole-2,6-dione
  • Iinagliptin Intermediate2
  • Linagliptin INT1
  • 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione/3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine
  • 8-Bromo-7-(2- butynyl)-3,7-dihydro- 3-methyl-1H-pur ine-2,6-dion
  • 8-BROMO-7-(BUT-2-YNYL)
  • 8-bromo-7-(but-2-ynyl)-3-methyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
  • 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
  • Linagliptin Impurity 36
  • 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dion
  • 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine &gt
  • 1H-Purine-2,6-dione, 8-bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-
  • 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
  • LINAGLIPTIN CAS 668270-12-0 INTERMEDIATES
  • 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione USP/EP/BP
  • Linagliptin intermediates，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
  • (2-(chloromethyl)-4-methylquinazoline)，8-bromo-7-(but-2-ynyl)-3-methyl-1H- purine-2,6(3H,7H)-dione
  • Linagliptin Impurity 73
  • 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1Hpurin-2,6(3H,7H)-dione
  • 8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-d...
  • 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine]Q: What is 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the CAS Number of 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine] Q: What is the storage condition of 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine]
  • 8-BROMO-3-METHYL-7-BUT-2-YNYL XANTHINE
  • 8-Bromo-7-But-2-Ynyl-3-Methyl-Purine-2,6-Dione / Linagliptin Intermediate
  • Hydrazinecarbothioamide,N-(10-methoxyphenyl)-
  • 8-bromo-7 -(2-butynyl) -3-methylxanthine
  • 8-bromo-3-methyl-7-(prop-1-yn-1-yl)-1H-purine-2,6(3H,7H)-dione
  • 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3
  • Linagliptin intermediate 8-bromo-7-but-2-yn-1-yl-3-methyl-3,7-dihydro-1H-purine-2,6-dione
  • 8-Bromo-7-(2-butynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
  • 666816-98-4
  • 666816-98-4