ChemicalBook > CAS DataBase List > 1,8-Diaminooctane

1,8-Diaminooctane

Product Name
1,8-Diaminooctane
CAS No.
373-44-4
Chemical Name
1,8-Diaminooctane
Synonyms
1,8-OCTANEDIAMINE;Octane-1,8-diamine;Xin diaMine;8-Diaminooctane;1,8-Oktandiamin;1,8-diaMine Xin;FENTAMINE HP-82;1,8- Octylamine;1,4-Octanediamine;1,8-DIAMINOOCTANE
CBNumber
CB2254212
Molecular Formula
C8H20N2
Formula Weight
144.26
MOL File
373-44-4.mol
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1,8-Diaminooctane Property

Melting point:
50-52 °C(lit.)
Boiling point:
225-226 °C(lit.)
Density 
0.98 g/mL at 20 °C
vapor pressure 
<0.1 hPa (20 °C)
refractive index 
1.4618 (estimate)
Flash point:
329 °F
storage temp. 
Store below +30°C.
solubility 
575g/l
form 
Solidified Crystalline Mass
pka
11.00, 10.1(at 20℃)
color 
White to yellow
PH
11.7 (4g/l, H2O, 20℃)
explosive limit
1.1-6.8%(V)
Water Solubility 
575 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
1735426
InChIKey
PWGJDPKCLMLPJW-UHFFFAOYSA-N
LogP
0.896 at 25℃
CAS DataBase Reference
373-44-4(CAS DataBase Reference)
NIST Chemistry Reference
1,8-Diaminooctane(373-44-4)
EPA Substance Registry System
1,8-Octanediamine (373-44-4)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-37/39
RIDADR 
UN 3259 8/PG 3
WGK Germany 
3
RTECS 
RG8841500
F 
3-9-23
Autoignition Temperature
280 °C DIN 51794
HazardClass 
8
PackingGroup 
III
HS Code 
29212900
Toxicity
LD50 orally in Rabbit: 500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D22401
Product name
1,8-Diaminooctane
Purity
98%
Packaging
25g
Price
$48.4
Updated
2025/07/31
Sigma-Aldrich
Product number
D22401
Product name
1,8-Diaminooctane
Purity
98%
Packaging
100g
Price
$123
Updated
2025/07/31
TCI Chemical
Product number
D0107
Product name
1,8-Diaminooctane
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
D0107
Product name
1,8-Diaminooctane
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$82
Updated
2025/07/31
TRC
Product number
D494060
Product name
1,8-Diaminooctane
Packaging
2.5g
Price
$75
Updated
2021/12/16
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1,8-Diaminooctane Chemical Properties,Usage,Production

Chemical Properties

white to yellowish solidified crystalline mass

Uses

1,8-Diaminooctane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Definition

ChEBI: 1,8-diaminooctane is an alkane-alpha,omega-diamine in which the two amino groups are separated by eight methylene groups. It derives from a hydride of an octane.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Asevere skin and eye irritant. When heated todecomposition it emits toxic vapors of NOx.

Synthesis

629-40-3

373-44-4

The general procedure for the synthesis of 1,8-octanediamine from 1,6-dicyanohexane was as follows: a 500 mL autoclave was assembled with a thermocouple thermometer, a stirrer (two-piece tilting paddle), a pressure gauge, and a hydrogen purge line. To the autoclave were added 175 g of 1,6-dicyanohexane, 86.0 g of methanol, 2.0 g of 28% sodium methacrylate-methanol solution (0.64% w/w), and 10.5 g of nickel catalyst (based on nickel monomers, which accounted for 6.0 w/w% of 1,6-dicyanohexane). The water content of the solution was 920 ppm at this point, as measured by a Karl Fischer hydrometer (manufactured by Hiranuma Sangyo Co., Ltd.) Upon completion of the dosing, hydrogen substitution was performed, and then the pressure was increased to 5 MPa. The temperature was raised to an internal temperature of 90 °C, and the ramping process lasted for approximately 1 hour. Hydrogen consumption was observed from about 70°C. The reaction was started at 90°C and hydrogen consumption essentially stopped after about 6 hours. After continuing the reaction for 2 hours, the reaction was cooled to room temperature, depressurized, and the reaction solution was filtered to remove the catalyst and the filtrate was washed with 100 g of methanol. The total weight of the 1,8-diaminooctane methanol reaction solution obtained was 377.4 g. The area of 1,8-diaminooctane was analyzed by GC to be 94.3% and the reaction yield was 96.7%.

Purification Methods

Distil the diamine under vacuum in an inert atmosphere (N2 or Ar), cool and store the distillate in an inert atmosphere in the dark. The dihydrochloride has m 273-274o. [Nae & Le Helv Chim Acta 15 55 1955, Beilstein 4 III 612.]

References

[1] Patent: JP2017/31143, 2017, A. Location in patent: Paragraph 0082; 0083; 0086; 0087
[2] Chemische Berichte, 1913, vol. 46, p. 230
[3] Patent: US6376714, 2002, B1
[4] Patent: US6376714, 2002, B1
[5] Patent: US2011/313186, 2011, A1. Location in patent: Page/Page column 11

1,8-Diaminooctane Preparation Products And Raw materials

Raw materials

Preparation Products

IMINOCTADINE TRIACETATE
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1,8-Diaminooctane Suppliers

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View Lastest Price from 1,8-Diaminooctane manufacturers

Weifang Integratechem Co., Ltd.
Product
1,8-Diaminooctane 373-44-4
Price
US $0.00/kg
Min. Order
800kg
Purity
99%
Supply Ability
35 ton/month
Release date
2025-08-22
Shaanxi Dideu Medichem Co. Ltd
Product
1,8-Diaminooctane 373-44-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2025-04-23
Hebei Chuanghai Biotechnology Co., Ltd
Product
1,8-Diaminooctane 373-44-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

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