ChemicalBook > CAS DataBase List > 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

Product Name
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
CAS No.
350797-56-7
Chemical Name
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
Synonyms
SL-5;Silodosin Nitro Impurity;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate;1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.;1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...;3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity);1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-
CBNumber
CB22546472
Molecular Formula
C22H23N3O4
Formula Weight
393.44
MOL File
350797-56-7.mol
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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Property

Melting point:
73-75°C
Boiling point:
608.6±55.0 °C(Predicted)
Density 
1.27
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
7.80±0.13(Predicted)
form 
Solid
color 
Light Yellow to Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C982035
Product name
3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propylBenzoate
Packaging
5g
Price
$135
Updated
2021/12/16
AK Scientific
Product number
J11149
Product name
SilodosinImpurity9
Packaging
25mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129703
Product name
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE
Purity
95.00%
Packaging
5MG
Price
$499.76
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129703
Product name
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE
Purity
95.00%
Packaging
25G
Price
$1000
Updated
2021/12/16
Chemenu
Product number
CM148068
Product name
3-(7-cyano-5-(2-nitropropyl)indolin-1-yl)propylbenzoate
Purity
95%
Packaging
5g
Price
$107
Updated
2021/12/16
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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Chemical Properties,Usage,Production

Uses

3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate is used in the preparation of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Synthesis

350797-55-6

350797-56-7

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde (20.0 g) was used as a starting material and dissolved in tetrahydrofuran (29.0 ml). To this solution, hydroxylamine hydrochloride (4.21 g) and pyridine (16.0 ml) were added sequentially. The reaction mixture was stirred at a constant temperature at 50 °C for 2 h. Acetic anhydride (9.0 ml) was subsequently added. Stirring of the reaction mixture was continued at 80°C for 2 hours. After completion of the reaction, extraction was carried out with toluene. The toluene layer obtained by extraction was washed with dilute hydrochloric acid, after which the solvent was removed by distillation under reduced pressure to give 16.0 g of propyl 3-(7-cyano-5-(2-nitropropyl)dihydroindol-1-yl)benzoate (Compound XX).

References

[1] Patent: WO2011/124704, 2011, A1. Location in patent: Page/Page column 19-20
[2] Patent: WO2013/56842, 2013, A1. Location in patent: Page/Page column 19
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3826 - 3839

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Suppliers

China 99 India 4 United States 1 Global 104
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
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0311-89250318 031166536426
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master@sjzsdyn.com
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China
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768836
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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021-60345187 13671753212
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Intelligence Pharm Science(Shanghai) Co., Ltd.
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021-57898186
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Nanjing Vital Chemical Co., Ltd.
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025-87193546 18652950785
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025-87193546
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chemweiao@163.com
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Shanghai QianYan Bio-technology Co., Ltd
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02781293128
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orders@biochemsafebuy.com
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Cangzhou Enke Pharma-tech Co., Ltd.
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0317-5296180 15533709196
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View Lastest Price from 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Silodosin 350797-56-7
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04

350797-56-7, 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrileRelated Search:

Silodosin Impurity 18 Silodosin β-D-Glucuronide N-Carboxybenzyl O-Methyl Tri-acetate Silodosin Impurity 26 NCFJJNFEEPMRAQ-XMMPIXPASA-N Silodosin 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Silodosin 1H-Indole-7-carbonitrile, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- O-Acetyl Silodosin 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-1H-indole-7-carboxaMide Silodosin Carboxylic Acid Impurity (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-1-(3-hydroxypropyl)indoline-7-carboxamide(WXG00186) Silodosin β-D-Glucuronide Sodium Salt Silodosin Glucuronide Silodosin-d4 (Chiral) 5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin Impurity 33 Silodosin-d6

  • 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate
  • SL-5
  • 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
  • 3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate
  • Silodosin Nitro Impurity
  • 1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-
  • 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...
  • 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity)
  • 1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.
  • 350797-56-7