1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1020174-04-2
Chemical Name: 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-Methylpyrazole-3-boronic Acid Pinacol Ester;1-Methylpyrazol-3-yl-boronic acid pinacol ester;(1-METHYL-1H-PYRAZOL-3-YL)BORONIC ACID PINACOL ESTER;1-Methyl-3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Methylpyrazol-3-yl-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane;1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-...;1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1H-Pyrazole, 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [M16052]
CBNumber: CB22549680
Molecular Formula: C10H17BN2O2
Formula Weight: 208.07
MOL File: 1020174-04-2.mol

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1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 308.3±15.0 °C(Predicted)
Density: 1.05
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 2.23±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-7-13(5)12-8/h6-7H,1-5H3
InChIKey: BJMSXWLXFYZHIU-UHFFFAOYSA-N
SMILES: N1(C)C=CC(B2OC(C)(C)C(C)(C)O2)=N1

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M330225
Product name: 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 2.5g
Price: $1540
Updated: 2021/12/16

ChemScene

Product number: CS-W000774
Product name: 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: >97.0%
Packaging: 1g
Price: $99
Updated: 2021/12/16

Apolloscientific

Product number: OR471694
Product name: 1-Methylpyrazole-3-boronicacidpinacolester
Purity: 98%
Packaging: 250mg
Price: $266
Updated: 2021/12/16

Matrix Scientific

Product number: 132017
Product name: 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 97%
Packaging: 1g
Price: $282
Updated: 2021/12/16

Synthonix

Product number: M16052
Product name: 1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 97.0%
Packaging: 5g
Price: $330
Updated: 2021/12/16

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1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Uses

1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is patented as a reagent to synthesize quinoxaline derivatives or heterocyclylamine derivatives as PI3 kinase inhibitors.

Synthesis

151049-87-5

73183-34-3

1020174-04-2

General procedure for the synthesis of 1-methylpyrazole-3-boronic acid pinacol ester from 3-bromo-1-methylpyrrole and bis(pinacolato)diboronic acid: firstly, compound 701 (3-bromo-1-methylpyrrole, 0.2 g, 1.24 mmol) was dissolved in 5 mL of 1,4-dioxane. Subsequently, bis(pinacolato)diboron (0.378 g, 1.49 mmol), potassium acetate (0.365 g, 3.72 mmol), and [1,1-bis(diphenylphosphino)ferrocene]palladium chloride dichloromethane complex (0.11 g, 0.124 mmol) were added to this solution. The reaction mixture was heated to 95 °C under nitrogen protection and kept at this temperature for 5 hours of reaction. After completion of the reaction, the mixture was cooled to room temperature. To the reaction mixture was added 15 mL of water, stirred for 1 hour and filtered to give 0.114 g of solid product, 1-methylpyrazole-3-boronic acid pinacol ester. The yield was 44.19%.

References

[1] Patent: EP3072893, 2016, A1. Location in patent: Paragraph 0394; 0395
[2] Patent: EP2818473, 2014, A1. Location in patent: Paragraph 0578

1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1020174-04-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1020174-04-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1020174-04-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-11

1020174-04-2, 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

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1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [M16052]

1020174-04-2