benzyl 2,4-difluorophenylcarbaMate
- Product Name
- benzyl 2,4-difluorophenylcarbaMate
- CAS No.
- 112434-18-1
- Chemical Name
- benzyl 2,4-difluorophenylcarbaMate
- Synonyms
- benzyl 2,4-difluorophenylcarbaMate;(2,4-Difluorophenyl)carbamic acid benzyl ester;Carbamic acid, N-(2,4-difluorophenyl)-, phenylmethyl ester
- CBNumber
- CB22552745
- Molecular Formula
- C14H11F2NO2
- Formula Weight
- 263.24
- MOL File
- 112434-18-1.mol
benzyl 2,4-difluorophenylcarbaMate Property
- Boiling point:
- 312.1±42.0 °C(Predicted)
- Density
- 1.329±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.69±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0368557
- Product name
- BENZYL-(2,4-DIFLUOROPHENYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.55
- Updated
- 2021/12/16
- Product number
- 071203
- Product name
- Benzyl 2,4-difluorophenylcarbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $615
- Updated
- 2021/12/16
- Product number
- 2182AA
- Product name
- Benzyl(2,4-difluorophenyl)carbamate
- Packaging
- 5g
- Price
- $1546
- Updated
- 2021/12/16
- Product number
- CM128599
- Product name
- benzyl(2,4-difluorophenyl)carbamate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1036
- Updated
- 2021/12/16
- Product number
- CD12179772
- Product name
- Benzyl(2,4-difluorophenyl)carbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1097
- Updated
- 2021/12/16
benzyl 2,4-difluorophenylcarbaMate Chemical Properties,Usage,Production
Synthesis
367-25-9
501-53-1
112434-18-1
To a 250 mL round bottom flask was added 2,4-difluoroaniline (11.4 g, 4.62 mL, 45.4 mmol), dichloromethane (DCM, 103 mL) and pyridine (7.40 mL, 91 mmol). The reaction mixture was stirred at room temperature and benzyl chloroformate (8.15 mL, 54.5 mmol) was slowly added dropwise through the addition funnel. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature overnight. Upon completion of the reaction, the mixture was poured into water and extracted with DCM. The organic phases were combined, washed sequentially with water and saturated saline, and then dried over anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to afford benzyl (2,4-difluorophenyl)-carbamate (11.1 g, 42.2 mmol, 93% yield) as a white solid, which could be used for subsequent reactions without further purification.LC-MS (ESI, positive ion mode) analysis: calculated value of C14H11F2NO2 [M+H]+: 263.1; Measured value: 263.1. measured value [M+Na]+: 286.1. 1H NMR (400 MHz, DMSO-d6) δ ppm: 9.43 (br s, 1H), 7.51-7.66 (m, 1H), 7.24-7.46 (m, 6H), 7.01-7.12 (m, 1H), 5.15 (s, 2H).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[2] Canadian Journal of Chemistry, 2009, vol. 87, # 2, p. 393 - 396
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 10, p. 2215 - 2234
[4] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2607 - 2610
[5] Patent: US2008/167338, 2008, A1. Location in patent: Page/Page column 44-45
benzyl 2,4-difluorophenylcarbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
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