5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide
Uses- Product Name
- 5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide
- CAS No.
- 1082745-50-3
- Chemical Name
- 5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide
- Synonyms
- EOS-62038;5-Amino-1-(tetrahydro-2H-pyran-4-yl);5-amino-1-(4-oxanyl)-4-pyrazolecarboxamide;5-amino-1-(oxan-4-yl)pyrazole-4-carboxamide;5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide;5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide;1H-Pyrazole-4-carboxamide, 5-amino-1-(tetrahydro-2H-pyran-4-yl)-;5-AMino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid aMide
- CBNumber
- CB22553595
- Molecular Formula
- C9H14N4O2
- Formula Weight
- 210.23
- MOL File
- 1082745-50-3.mol
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide Property
- Boiling point:
- 453.4±45.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 15.14±0.50(Predicted)
- Appearance
- light yellow solid
Safety
- HS Code
- 2922390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A630998
- Product name
- 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- OR310332
- Product name
- 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide
- Packaging
- 500mg
- Price
- $419
- Updated
- 2021/12/16
- Product number
- 4H48-1-MF
- Product name
- 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide
- Packaging
- 500mg
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 35445
- Product name
- 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- OR310332
- Product name
- 5-Amino-1-(oxan-4-yl)-1H-pyrazole-4-carboxamide
- Packaging
- 1g
- Price
- $568
- Updated
- 2021/12/16
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide Chemical Properties,Usage,Production
Uses
5-Amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide is an amide organic compound that can be used as a pharmaceutical intermediate.
Synthesis
1082745-49-0
1082745-50-3
General procedure for the synthesis of 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile as 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide: 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carbonitrile (<228 mmol, the crude product from the previous reaction) was dissolved in ethanol ( 300 mL) in a 35% aqueous hydrogen peroxide solution (100 mL) and concentrated ammonia (300 mL) were added sequentially. The reaction mixture was stirred at room temperature for 48 h. The reaction was subsequently quenched with saturated aqueous sodium thiosulfate solution (800 mL). Ethanol was removed by distillation under reduced pressure and the resulting solid was separated by filtration and washed with water (2 x 200 mL) and ether (2 x 150 mL) to afford 5-amino-1-(tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid amide (31 g, 147 mmol). The overall yield of the two-step reaction from the starting material to the target product was 64%.ESI-MS (M-H)-: 211 (calculated value C9H14N4O2: 210.1).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 21, p. 9045 - 9054
[2] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 151
[3] Patent: WO2014/16789, 2014, A1. Location in patent: Page/Page column 21
[4] Patent: US2017/291901, 2017, A1. Location in patent: Paragraph 0168; 0169
[5] Patent: US2009/30003, 2009, A1. Location in patent: Page/Page column 36
5-aMino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxaMide Preparation Products And Raw materials
Raw materials
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