3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
- Product Name
- 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
- CAS No.
- 442903-28-8
- Chemical Name
- 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
- Synonyms
- Methyl 2,4-dichloropyridine-3-carboxylate;2,4-dichloro-, Methyl ester;4-dichloropyridine-3-carboxylate;Methyl 2,4-dichloronicotinic acid;2,4-Dichloro nicotinic acid Methyl ester;2,4-Dichloro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester;Methyl 2,4-dichloropyridine-3-carboxylate, 2,4-Dichloro-3-(methoxycarbonyl)pyridine
- CBNumber
- CB22554082
- Molecular Formula
- C7H5Cl2NO2
- Formula Weight
- 206.03
- MOL File
- 442903-28-8.mol
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Property
- Boiling point:
- 266.2±35.0 °C(Predicted)
- Density
- 1.426±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.24±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H5Cl2NO2/c1-12-7(11)5-4(8)2-3-10-6(5)9/h2-3H,1H3
- InChIKey
- IBZIEMCFERTPNR-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(Cl)=C1C(OC)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M301400
- Product name
- Methyl2,4-dichloronicotinate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- M301400
- Product name
- Methyl2,4-dichloronicotinate
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- OR46030
- Product name
- Methyl2,4-dichloronicotinate
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 047150
- Product name
- Methyl 2,4-dichloronicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $603
- Updated
- 2021/12/16
- Product number
- W6318
- Product name
- methyl2,4-dichloronicotinate
- Packaging
- 10g
- Price
- $717
- Updated
- 2021/12/16
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Chemical Properties,Usage,Production
Synthesis
262423-77-8
74-88-4
442903-28-8
GENERAL STEPS: 2,4-Dichloronicotinic acid (500 mg, 2.60 mmol) was dissolved in acetonitrile (10 mL) and cooled to 0°C. Subsequently, DBU (0.981 mL, 6.51 mmol) and iodomethane (0.814 mL, 13.0 mmol) were sequentially added to the solution. The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (10 mL), washed once with water (5 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate-hexane) to afford methyl 2,4-dichloronicotinate (260 mg, 1.262 mmol, 49% yield) as a light yellow oil.LC/MS (ESI) m/z 206.1 [(M + H)+, calculated value of 205.97 for C7H6Cl2NO2]; LC/MS retention time ( Method D): tR = 0.85 min. 1H NMR (300 MHz, CD3OD) δ ppm 8.42 (d, J = 5.4 Hz, 1H), 7.59 (d, J = 5.4 Hz, 1H), 3.99 (s, 3H).
References
[1] Tetrahedron Letters, 2011, vol. 52, # 4, p. 523 - 525
[2] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 92
[3] Patent: JP2015/528018, 2015, A. Location in patent: Paragraph 0190
[4] Patent: WO2017/218960, 2017, A1. Location in patent: Paragraph 00607
3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester manufacturers
- Product
- 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester 442903-28-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14