5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- Product Name
- 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS No.
- 475488-23-4
- Chemical Name
- 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- Synonyms
- ADW;CS-467;ADW 742;NVP-ADW7;GSK 552602A;NVP-ADW742 b;NVP-ADW742(ADW742);GSK 552602A; ADW742;ADW 742 GSK 552602A;5-(3-(Benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)-cyclobutyl)-7H-pyrrolo[2,3-d]pyri
- CBNumber
- CB22554264
- Molecular Formula
- C28H31N5O
- Formula Weight
- 453.58
- MOL File
- 475488-23-4.mol
5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Property
- Boiling point:
- 677.5±55.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 10.00±0.20(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1921
- Product name
- NVP-ADW742
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML1921
- Product name
- NVP-ADW742
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2024/03/01
- Product number
- 18390
- Product name
- NVP-ADW742
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 18390
- Product name
- NVP-ADW742
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 18390
- Product name
- NVP-ADW742
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $188
- Updated
- 2024/03/01
5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Properties,Usage,Production
Uses
NVP-ADW742 is an IGF-1R inhibitor with IC50?of 0.17 μM.
Biological Activity
nvp-adw742 is a novel inhibitor of ifg-1receptor (igf-1r) kinase with the ic50 value of 0.17μm [1].nvp-adw742 has shown above 16-fold effective function against igf-1r than insulin receptor (insr). furthermore, nvp-adw742 has also been reported to inhibit other kinases , with the ic50 values of ＞10μm for her2, pdgfr, vegfr-2, or bcr-abl p210, and the ic50 values ＞5μm for c-kit [1]. besides, nvp-adw742 combined with etoposide and carboplatin has been reported to inhibit cell growth and induce cytotoxicity by mtt assay using the small cell lung cancer (sclc), including h526, h146, wba and h209 cell lines. in addition, nvp-adw742 has been revealed to completely inhibit the expression of vegf mrna which induced by igf-i in h526 cells [2].
storage
Store at -20°C
References
[1] mitsiades cs1, mitsiades ns, mcmullan cj, poulaki v, shringarpure r, akiyama m, hideshima t, chauhan d, joseph m, libermann ta, garcía-echeverría c, pearson ma, hofmann f, anderson kc, kung al. inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors . cancer cell. 2004 mar; 5(3):221-30.
[2]warshamana-greene gs1, litz j, buchdunger e, garcía-echeverría c, hofmann f, krystal gw. the insulin-like growth factor-i receptor kinase inhibitor, nvp-adw742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. clin cancer res. 2005 feb 15;11(4):1563-71.
5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1493
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
View Lastest Price from 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine manufacturers
- Product
- 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 475488-23-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02