ChemicalBook > CAS DataBase List > (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

Product Name
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
CAS No.
779353-01-4
Chemical Name
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Synonyms
Dinaciclib;Sch 727965;CS-213;PS-095760;Dinaciclib, >=98%;SCH 727965DINACICLIB;Dinaciclib (SCH 727965);Dinaciclib (SCH727965), ≥98%;SCH 727965; SCH727965; SCH-727965;DINACICLIB (SCH727965);SCH 727965
CBNumber
CB22554279
Molecular Formula
C21H28N6O2
Formula Weight
396.49
MOL File
779353-01-4.mol
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(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Property

Melting point:
>78oC (dec.)
Density 
1.33
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
15.15±0.10(Predicted)
form 
Solid
color 
White to Light Beige
Stability:
Hygroscopic
CAS DataBase Reference
779353-01-4
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H340May cause genetic defects

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14707
Product name
Dinaciclib
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
14707
Product name
Dinaciclib
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
14707
Product name
Dinaciclib
Purity
≥98%
Packaging
25mg
Price
$412
Updated
2024/03/01
Tocris
Product number
7336
Product name
Dinaciclib
Purity
≥98%(HPLC)
Packaging
10
Price
$139
Updated
2021/12/16
Usbiological
Product number
163876
Product name
Dinaciclib
Packaging
5mg
Price
$389
Updated
2021/12/16
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(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Chemical Properties,Usage,Production

Uses

Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics.

Definition

ChEBI: 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol is a pyrazolopyrimidine.

Biological Activity

dinaciclib is a potent cyclin-dependent kinase (cdk) inhibitor with ic50s for cdk2, cdk5, cdk1 and cdk9 at 1 nm, 1 nm, 3 nm, and 4 nm, respectively. [1] it is in phase i or ii

target

CDK2

storage

Store at -20°C

References

[1]parry d., et al. (2010). dinaciclib (sch 727965), a novel and potent cyclin-dependent kinase inhibitor. mol cancer ther (9): 2344- 2353.
[2]martin, m. p., et al. (2013). cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. acs chemical biology 8 (11): 2360–5.
[3]payton m., et al. (2006). discovery and evaluation of dual cdk1 and cdk2 inhibitors. cancer res 66: 4299-4308.

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Suppliers

Canada 1 China 132 India 1 United Kingdom 1 United States 19 Global 154
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View Lastest Price from (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 779353-01-4
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Henan Aochuang Chemical Co.,Ltd.
Product
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 779353-01-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 779353-01-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

779353-01-4, (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanolRelated Search:

4'-Hydroxyacetophenone SPINETORAM MK-2206 2HCl AZD 5438 Trametinib PD 0332991 HCl Flavopiridol (Alvocidib) HCl Roscovitine

  • (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965)
  • 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-
  • Dinaciclib, >=98%
  • DINACICLIB (SCH727965);SCH 727965
  • (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
  • (S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methy
  • Dinaciclib (SCH727965), ≥98%
  • CS-213
  • SCH 727965; SCH727965; SCH-727965
  • SCH 727965;SCH727965;SCH-727965;PS-095760
  • Dinaciclib
  • Sch 727965
  • PS-095760
  • (S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide
  • SCH 727965DINACICLIB
  • DINACICLIB(SCH-727965, PS-095760)
  • 3-[({8-ethyl-2-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrrolo[1,2-a]pyriMidin-4-yl}aMino)Methyl]pyridin-1-iuM-1-olate
  • Dinaciclib (SCH 727965)
  • 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
  • (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol ISO 9001：2015 REACH
  • inhibit,Dinaciclib,SCH727965,Inhibitor,SCH-727965,Cyclin dependent kinase,CDK,Apoptosis
  • 779353-01-4
  • C21H28N6O2
  • Inhibitors