Amiodarone-D4 HCl

Product Name: Amiodarone-D4 HCl
CAS No.: 1216715-80-8
Chemical Name: Amiodarone-D4 HCl
Synonyms: Prosulfocarb Impurity 3-d10;D4-Amiodarone Hydrochloride;Amiodarone hydrochloride salt;[2H4]-Amiodarone Hydrochloride;Amiodarone-D4 hydrochloride solution;Amiodarone-D₄ hydrochloride solution;Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
CBNumber: CB22560799
Molecular Formula: C25H30ClI2NO3
Formula Weight: 681.78
MOL File: 1216715-80-8.mol

More

Less

Amiodarone-D4 HCl Property

Flash point:: 9℃
storage temp.: -20°C
solubility: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
form: A solid
color: White to off-white
Stability:: Very Hygroscopic

More

Less

Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A-083
Product name: Amiodarone-D4 hydrochloride solution
Purity: 100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1ML
Price: $243
Updated: 2025/07/31

Cayman Chemical

Product number: 10010668
Product name: Amiodarone-d4 (hydrochloride)
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 1mg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 10010668
Product name: Amiodarone-d4 (hydrochloride)
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 5mg
Price: $724
Updated: 2024/03/01

TRC

Product number: A632952
Product name: Amiodarone-d4Hydrochloride
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

TRC

Product number: A632952
Product name: Amiodarone-d4Hydrochloride
Packaging: 25mg
Price: $1390
Updated: 2021/12/16

More

Less

Amiodarone-D4 HCl Chemical Properties,Usage,Production

Description

Amiodarone-d₄ is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC₅₀ value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ⁸Δ⁷ isomerase, and C-8 sterol isomerase (K_is = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC₅₀s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

Uses

A Labelled non-selective ion channel blocker. Antiarrhythmic (class III).

General Description

A Certified Spiking Solution^?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone^?, Cordarone^?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

References

[1] T. J. CAMPBELL K. M W. Therapeutic drug monitoring: antiarrhythmic drugs[J]. British journal of clinical pharmacology, 2003, 46 4: 307-319. DOI: 10.1046/j.1365-2125.1998.t01-1-00768.x
[2] NANDITA SINHA Srikanta S. Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR model[J]. European Journal of Medicinal Chemistry, 2011, 46 2: Pages 618-630. DOI: 10.1016/j.ejmech.2010.11.042
[3] CHRISTIAN LAGGNER. Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening[J]. Journal of Medicinal Chemistry, 2005, 48 15: 4754-4764. DOI: 10.1021/jm049073+
[4] BO CARLSSON. Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with Amiodarone[J]. Journal of Medicinal Chemistry, 2002, 45 3: 623-630. DOI: 10.1021/jm001126+
[5] THOMAS M POLASEK. Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 311 3: 996-1007. DOI: 10.1124/jpet.104.071803

Amiodarone-D4 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Amiodarone-D4 HCl Suppliers

Canada 2 China 30 India 4 United States 5 Global 41

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Nanjing Haolv Biotechnology Co.,Ltd

Tel: 025-84622273 17361806303
Email: kexin.zhou@haolvbiotech.com
Country: China
ProdList: 3019
Advantage: 58

Shenzhen Kaimingke Biotechnology Co., Ltd.

Tel: 181-26439142 18126439142
Email: 1144496688@QQ.COM
Country: China
ProdList: 170
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

ChengDu SinoStandards Bio-Tech Co.,Ltd. ，

Tel: 028-83243028 19136088901
Email: sinostandards@163.com
Country: China
ProdList: 4976
Advantage: 58

Manhag Testing Technology Co., Ltd

Tel: 020-3846 2365 19110442770
Email: 458677837@qq.com
Country: China
ProdList: 7775
Advantage: 58

Yancheng Tongming Biotechnology Co., Ltd.

Tel: 15195160625
Email: 2863565288@qq.com
Country: China
ProdList: 5192
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7259
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Shanghai isotope chemical co.,ltd

Tel: 021-51600108 13062666369
Email: sales@isotopechem.com
Country: China
ProdList: 5000
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9651
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9119
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12064
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

BePure (Beijing) Biotechnology Co.

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 6620
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9980
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

ShangHai ZskBio CO., LTD

Tel: 021-58056897 15399714481
Email: info@zsklab.com
Country: China
ProdList: 7190
Advantage: 58

Guangzhou New Century Technology Co., Ltd.

Tel: 020-13113998854 13113998854
Email: 1094589719@qq.com
Country: China
ProdList: 145
Advantage: 58

Tianjin Baibei Biotechnology Co., Ltd.

Tel: 15302170631
Country: CHINA
ProdList: 166
Advantage: 58

Shanghai Xiyuan Biotechnology Co., Ltd

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6934
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

1216715-80-8, Amiodarone-D4 HClRelated Search:

1-Methoxy AMiodarone 3-(4-HYDROXY-3-IODOBENZOYL)-2-BUTYLBENZOFURAN Amiodarone Amiodarone hydrochloride [[p-(2-methoxyethyl)phenoxy]methyl]oxirane Desethyl Amiodarone Hydrochloride N-Desethylamiodarone-D4 HCl Bis Des-iodo amiodarone HCl(Amiodarone impurity) (2-butylbenzofuran-3-yl) (4-methoxyphenyl) ketone Amiodarone Impurity 13 2-Butyl-3-(3,5-Diiodo-4-hydroxy benzoyl) benzofuran Di(N-desethyl) AMiodarone Hydrochloride 2-Butylbenzofuran 2-Diethylaminoethylchloride hydrochloride 2-Butyl-3-(4-hydroxybenzoyl)benzofuran Dideiodo AMiodarone Hydrochloride Amiodarone Impurity 2 Amiodarone N-oxide

Amiodarone-D4 hydrochloride solution

(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride

AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)

[2H4]-Amiodarone Hydrochloride

Amiodarone hydrochloride salt

Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride

Prosulfocarb Impurity 3-d10

Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol

Amiodarone-D<sub>4</sub> hydrochloride solution

D4-Amiodarone Hydrochloride

1216715-80-8