ChemicalBook > CAS DataBase List > Amiodarone-D4 HCl

Amiodarone-D4 HCl

Product Name
Amiodarone-D4 HCl
CAS No.
1216715-80-8
Chemical Name
Amiodarone-D4 HCl
Synonyms
Prosulfocarb Impurity 3-d10;Amiodarone hydrochloride salt;[2H4]-Amiodarone Hydrochloride;Amiodarone-D4 hydrochloride solution;Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
CBNumber
CB22560799
Molecular Formula
C25H30ClI2NO3
Formula Weight
681.78
MOL File
1216715-80-8.mol
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Amiodarone-D4 HCl Property

Flash point:
9℃
storage temp. 
-20°C
solubility 
DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
form 
A solid
color 
White to off-white
Stability:
Very Hygroscopic
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A-083
Product name
Amiodarone-D4 hydrochloride solution
Purity
100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1ML
Price
$238
Updated
2024/03/01
Cayman Chemical
Product number
10010668
Product name
Amiodarone-d4 (hydrochloride)
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
10010668
Product name
Amiodarone-d4 (hydrochloride)
Purity
≥99% deuterated forms (d1-d4)
Packaging
5mg
Price
$724
Updated
2024/03/01
TRC
Product number
A632952
Product name
Amiodarone-d4Hydrochloride
Packaging
2.5mg
Price
$180
Updated
2021/12/16
TRC
Product number
A632952
Product name
Amiodarone-d4Hydrochloride
Packaging
25mg
Price
$1390
Updated
2021/12/16
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Amiodarone-D4 HCl Chemical Properties,Usage,Production

Description

Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

Uses

A Labelled non-selective ion channel blocker. Antiarrhythmic (class III).

General Description

A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

Amiodarone-D4 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Amiodarone-D4 HCl Suppliers

Canada 2 China 25 India 4 United States 5 Global 36
Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.
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Shenzhen SUNGENING Bio-Medical Co., Ltd.
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Nanjing Haolv Biotechnology Co.,Ltd
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Energy Chemical
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ChengDu SinoStandards Bio-Tech Co.,Ltd. ，
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Cato Research Chemicals Inc.
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1216715-80-8, Amiodarone-D4 HClRelated Search:

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  • Amiodarone-D4 hydrochloride solution
  • (2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride
  • AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)
  • [2H4]-Amiodarone Hydrochloride
  • Amiodarone hydrochloride salt
  • Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
  • Prosulfocarb Impurity 3-d10
  • Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol
  • 1216715-80-8