5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid

Product Name: 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid
CAS No.: 376592-58-4
Chemical Name: 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid
Synonyms: Eltrombopag int1;Eltrombopag Impurity 39;Eltrombopag Impurity 15;3-(5-chloro-2-hydroxy-3-nitrophenyl)benzoicaci;3-(5-chloro-2-hydroxy-3-nitrophenyl)benzoic acid;5’-Chloro-2’-hydroxy-3’-nitrobiphenyl-3-carboxylic Acid;5'-Chloro-2'-hydroxy-3'-nitrobiphenyl-3-carboxylic acid; 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid;5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic acid;5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic ac...
CBNumber: CB22563275
Molecular Formula: C13H8ClNO5
Formula Weight: 293.66
MOL File: 376592-58-4.mol

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5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid Property

Boiling point:: 467.4±45.0 °C(Predicted)
Density: 1.549±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.89±0.10(Predicted)
InChI: InChI=1S/C13H8ClNO5/c14-9-5-10(12(16)11(6-9)15(19)20)7-2-1-3-8(4-7)13(17)18/h1-6,16H,(H,17,18)
InChIKey: PGNTVCRTPYDGRN-UHFFFAOYSA-N
SMILES: C1(C2=CC(Cl)=CC([N+]([O-])=O)=C2O)=CC=CC(C(O)=O)=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC159731
Product name: 5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
Packaging: 1g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC159731
Product name: 5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
Packaging: 2g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC159731
Product name: 5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
Packaging: 5G
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC159731
Product name: 5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
Packaging: 10g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC159731
Product name: 5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
Packaging: 25g
Price: $300
Updated: 2021/12/16

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5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid Chemical Properties,Usage,Production

Synthesis

376592-57-3

376592-58-4

5'-Chloro-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (Compound 2a, 2.31 g, 9.3 mmol) was used as a raw material and suspended in a mixed solution of 50% sulfuric acid (15 mL) and acetic acid (120 mL). Subsequently, a solution of sodium nitrate (NaNO3, 1.70 g, 20 mmol) dissolved in 25% sulfuric acid (6.5 mL) was slowly added to this suspension. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the mixture was diluted with water (150 mL) to induce precipitation of the product. The precipitate was collected by filtration, washed with water and dried to afford the target product 5'-chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid (Compound 2b) as a yellow-green solid (2.53 g, 92% yield, 97% purity, HPLC Method B). The structure of the product was determined by 1H-NMR (DMSO-d6) δ: 7.58 (t, J = 7.7 Hz, 1H), 7.75-7.78 (m, 2H), 7.97 (td, J1 = 1.4, J2 = 7.7 Hz, 1H), 8.05 (d, J = 2.7 Hz, 1H), 8.09 (t, J = 1.5 Hz, 1H), 10.73 (s , 1H), 12.98 (s, 1H) ppm; 13C-NMR (150 MHz, DMSO-d6) δ: 123.75,124.23,129.22,129.48,130.75,131.28,134.21,134.24,135.91,136.48,137.80,149.17, 167.50 ppm; mass spectrum (MS) m/z [M-H]? : 292.0 Confirmed.

References

[1] Patent: WO2013/49605, 2013, A1. Location in patent: Paragraph 0052

5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid Preparation Products And Raw materials

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View Lastest Price from 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid 376592-58-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid 376592-58-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-08-06

376592-58-4, 5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acidRelated Search:

XDXWLKQMMKQXPV-PHYJMDTMSA-N 3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride

5-Chloro-2-hydroxy-3-nitro-(1,1-biphenyl)-3-carboxylic acid

[1,1'-Biphenyl]-3-carboxylic acid, 5'-chloro-2'-hydroxy-3'-nitro

Eltrombopag int1

5'-Chloro-2'-hydroxy-3'-nitrobiphenyl-3-carboxylic acid

5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic acid

3-(5-chloro-2-hydroxy-3-nitrophenyl)benzoic acid

Eltrombopag Impurity 15

Eltrombopag Impurity 39

3-(5-chloro-2-hydroxy-3-nitrophenyl)benzoicaci

5'-Chloro-2'-hydoxy-3'-nitro-(1,1'-biphenyl)-3-Carboxylic ac...

5’-Chloro-2’-hydroxy-3’-nitrobiphenyl-3-carboxylic Acid

5'-Chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid

376592-58-4