4-Chloro-2-methylphenylboronic acid pinacol ester

Product Name: 4-Chloro-2-methylphenylboronic acid pinacol ester
CAS No.: 1030832-75-7
Chemical Name: 4-Chloro-2-methylphenylboronic acid pinacol ester
Synonyms: 4-Chloro-2-methylphenylboronic acid pinacol ester;4-Chloro-2-methylphenylboronic acid, pinacol ester 95+%;2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-(4-chloro-2-methylphenyl)-4,4,5,5-tetramethyl-
CBNumber: CB22564818
Molecular Formula: C13H18BClO2
Formula Weight: 252.54
MOL File: 1030832-75-7.mol

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4-Chloro-2-methylphenylboronic acid pinacol ester Property

Boiling point:: 330.4±35.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C587478
Product name: 4-Chloro-2-methylphenylboronicAcidPinacolEster
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C587478
Product name: 4-Chloro-2-methylphenylboronicAcidPinacolEster
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: Z6587
Product name: 4-Chloro-2-methylphenylboronicacidpinacolester
Packaging: 1g
Price: $91
Updated: 2021/12/16

Apolloscientific

Product number: OR360972
Product name: 4-Chloro-2-methylphenylboronic acid, pinacol ester
Purity: 95+%
Packaging: 5g
Price: $131
Updated: 2021/12/16

Apolloscientific

Product number: OR360972
Product name: 4-Chloro-2-methylphenylboronic acid, pinacol ester
Purity: 95+%
Packaging: 10g
Price: $195
Updated: 2021/12/16

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4-Chloro-2-methylphenylboronic acid pinacol ester Chemical Properties,Usage,Production

Synthesis

76-09-5

209919-30-2

1030832-75-7

General procedure for the synthesis of 2-(4-chloro-2-methyl-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane from pinacol and 2-methyl-4-chlorophenylboronic acid: 4-chloro-2-methylphenylboronic acid (5.0 g, 29 mmol) and 100 mL of diethyl ether were placed in a round-bottom flask. Pinacol (3.43 g, 29 mmol, 1 eq.) was then added and the resulting reaction mixture was stirred for several minutes until the solution became clear. Next, anhydrous magnesium sulfate (6.98 g, 58 mmol, 2 eq.) was added and stirred at room temperature under nitrogen protection overnight. 24 h later, the reaction mixture was post-treated: the magnesium sulfate was removed by filtration and washed with diethyl ether. After combining the organic layers, the solvent was removed by concentration under reduced pressure to give the pure product (7.2 g, 97% yield) as a white powder. The structure of the product was confirmed by the following method: RP-HPLC analytical conditions: HP 1100 HPLC system equipped with a Waters 3.9×150 mm NovaPak HR C18 column and guard column, injection volume of 0.010 mL, flow rate of 1.5 mL/min, injection loop volume of 1.500 mL, detection wavelength of 254 nm. mobile phase A was water (with 0.1% v/v TFA), mobile phase B was acetonitrile (containing 0.1% v/v TFA), gradient elution program: initial 10% B held for 1 min, 10-80% B linear gradient eluted for 9 min, 80-100% B linear gradient eluted for 1 min, 100% B was held for 1 min, and the retention time of the product was 12.6 min.1H NMR (400 MHz, CDCl3) δ: 1.33 (0.010 mL, 1.5 mL/min). ) δ: 1.33 (s, 12H), 2.50 (s, 3H), 7.14 (m, 2H), 7.68 (d, 1H).

References

[1] Patent: WO2008/66921, 2008, A2. Location in patent: Page/Page column 78-79

4-Chloro-2-methylphenylboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1030832-75-7, 4-Chloro-2-methylphenylboronic acid pinacol esterRelated Search:

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