4-Chloro-2-methylphenylboronic acid pinacol ester
- Product Name
- 4-Chloro-2-methylphenylboronic acid pinacol ester
- CAS No.
- 1030832-75-7
- Chemical Name
- 4-Chloro-2-methylphenylboronic acid pinacol ester
- Synonyms
- 4-Chloro-2-methylphenylboronic acid pinacol ester;4-Chloro-2-methylphenylboronic acid, pinacol ester 95+%;2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-(4-chloro-2-methylphenyl)-4,4,5,5-tetramethyl-
- CBNumber
- CB22564818
- Molecular Formula
- C13H18BClO2
- Formula Weight
- 252.54
- MOL File
- 1030832-75-7.mol
4-Chloro-2-methylphenylboronic acid pinacol ester Property
- Boiling point:
- 330.4±35.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C587478
- Product name
- 4-Chloro-2-methylphenylboronicAcidPinacolEster
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C587478
- Product name
- 4-Chloro-2-methylphenylboronicAcidPinacolEster
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR360972
- Product name
- 4-Chloro-2-methylphenylboronic acid, pinacol ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- Z6587
- Product name
- 4-Chloro-2-methylphenylboronicacidpinacolester
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- OR360972
- Product name
- 4-Chloro-2-methylphenylboronic acid, pinacol ester
- Purity
- 95+%
- Packaging
- 10g
- Price
- $195
- Updated
- 2021/12/16
4-Chloro-2-methylphenylboronic acid pinacol ester Chemical Properties,Usage,Production
Synthesis
76-09-5
209919-30-2
1030832-75-7
General procedure for the synthesis of 2-(4-chloro-2-methyl-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane from pinacol and 2-methyl-4-chlorophenylboronic acid: 4-chloro-2-methylphenylboronic acid (5.0 g, 29 mmol) and 100 mL of diethyl ether were placed in a round-bottom flask. Pinacol (3.43 g, 29 mmol, 1 eq.) was then added and the resulting reaction mixture was stirred for several minutes until the solution became clear. Next, anhydrous magnesium sulfate (6.98 g, 58 mmol, 2 eq.) was added and stirred at room temperature under nitrogen protection overnight. 24 h later, the reaction mixture was post-treated: the magnesium sulfate was removed by filtration and washed with diethyl ether. After combining the organic layers, the solvent was removed by concentration under reduced pressure to give the pure product (7.2 g, 97% yield) as a white powder. The structure of the product was confirmed by the following method: RP-HPLC analytical conditions: HP 1100 HPLC system equipped with a Waters 3.9×150 mm NovaPak HR C18 column and guard column, injection volume of 0.010 mL, flow rate of 1.5 mL/min, injection loop volume of 1.500 mL, detection wavelength of 254 nm. mobile phase A was water (with 0.1% v/v TFA), mobile phase B was acetonitrile (containing 0.1% v/v TFA), gradient elution program: initial 10% B held for 1 min, 10-80% B linear gradient eluted for 9 min, 80-100% B linear gradient eluted for 1 min, 100% B was held for 1 min, and the retention time of the product was 12.6 min.1H NMR (400 MHz, CDCl3) δ: 1.33 (0.010 mL, 1.5 mL/min). ) δ: 1.33 (s, 12H), 2.50 (s, 3H), 7.14 (m, 2H), 7.68 (d, 1H).
References
[1] Patent: WO2008/66921, 2008, A2. Location in patent: Page/Page column 78-79
4-Chloro-2-methylphenylboronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-methylphenylboronic acid pinacol ester Suppliers
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 18681884732
- Fax
- 021-51632502
- 2245256225@qq.com
- Country
- China
- ProdList
- 1728
- Advantage
- 50
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 025-66800956 18800000000
- Fax
- qq3325708371
- sales@njdmchem.com
- Country
- China
- ProdList
- 4200
- Advantage
- 50
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 19951936396
- 1815156226@qq.com
- Country
- China
- ProdList
- 2947
- Advantage
- 58