3-broMo-5-fluoro-4-hydroxybenzaldehyde
- Product Name
- 3-broMo-5-fluoro-4-hydroxybenzaldehyde
- CAS No.
- 185345-46-4
- Chemical Name
- 3-broMo-5-fluoro-4-hydroxybenzaldehyde
- Synonyms
- 3-fluoro-4-hydroxy-5-bromobenzaldehyde;3-broMo-5-fluoro-4-hydroxybenzaldehyde;Benzaldehyde, 3-bromo-5-fluoro-4-hydroxy-
- CBNumber
- CB22565572
- Molecular Formula
- C7H4BrFO2
- Formula Weight
- 219.01
- MOL File
- 185345-46-4.mol
3-broMo-5-fluoro-4-hydroxybenzaldehyde Property
- Boiling point:
- 238.9±35.0 °C(Predicted)
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.00±0.23(Predicted)
- Appearance
- Off-white to light brown Powder
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B686838
- Product name
- 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC905038
- Product name
- 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- PC905038
- Product name
- 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- Z4328
- Product name
- 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $258
- Updated
- 2021/12/16
- Product number
- Z4328
- Product name
- 3-Bromo-5-fluoro-4-hydroxybenzaldehyde
- Packaging
- 10g
- Price
- $462
- Updated
- 2021/12/16
3-broMo-5-fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production
Uses
3-Bromo-5-fluoro-4-hydroxybenzaldehyde can be used to prepare derivatives to treat malignant tumor, as well as, CRTH2 receptor inhibitors to treat inflammatory disorders.
Synthesis
405-05-0
185345-46-4
Synthesis of 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26): 3-fluoro-4-hydroxybenzaldehyde (2 g, 14.3 mmol, 1 eq.) was dissolved in acetic acid (60 mL) and bromine (2.7 g, 17.0 mmol, 1.2 eq.) was added slowly to a solution of acetic acid (10 mL). The reaction mixture was stirred at 45°C for 26 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure and saturated saline (50 mL) was added to the residue and extracted with ethyl acetate (3 x 80 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by reversed-phase semi-preparative high-performance liquid chromatography (HPLC) to afford the target product 3-bromo-5-fluoro-4-hydroxybenzaldehyde (26) 1.5 g in 48% yield.
References
[1] Patent: WO2010/102154, 2010, A2. Location in patent: Page/Page column 56
[2] Patent: WO2011/2814, 2011, A2. Location in patent: Page/Page column 48
3-broMo-5-fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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