1-(ethoxycarbonyl)cyclopropanecarboxylic acid
- Product Name
- 1-(ethoxycarbonyl)cyclopropanecarboxylic acid
- CAS No.
- 3697-66-3
- Chemical Name
- 1-(ethoxycarbonyl)cyclopropanecarboxylic acid
- Synonyms
- Ethyl cyclopropane-1,1-dicarboxylate;Monoethyl 1,1-cyclopropanedicarboxylate;hoxycarbonyl)cyclopropanecarboxylic acid;1-(ethoxycarbonyl)cyclopropanecarboxylic acid;Cyclopropane-1,1-dicarboxylic acid ethyl ester;1,1-Cyclopropanedicarboxylic acid, 1-ethyl ester;2-METHYL-2-PROPANYL [(3R)-3-MORPHOLINYLMETHYL]CARBAMATE;1-(Ethoxycarbonyl)Cyclopropanecarboxylic Acid(WXC03382)
- CBNumber
- CB22565941
- Molecular Formula
- C7H10O4
- Formula Weight
- 158.15
- MOL File
- 3697-66-3.mol
1-(ethoxycarbonyl)cyclopropanecarboxylic acid Property
- Boiling point:
- 66-69℃ (0.15 Torr)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.46±0.20(Predicted)
- form
- liquid
- color
- Clear, colourless
Safety
- HS Code
- 2917200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939680
- Product name
- 1-(Ethoxycarbonyl)cyclopropanecarboxylicacid
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-W000595
- Product name
- 1-(Ethoxycarbonyl)cyclopropane-1-carboxylicacid
- Packaging
- 5g
- Price
- $479
- Updated
- 2021/12/16
- Product number
- W5814
- Product name
- 1-(Ethoxycarbonyl)cyclopropanecarboxylicacid
- Packaging
- 25g
- Price
- $491
- Updated
- 2021/12/16
- Product number
- W5814
- Product name
- 1-(Ethoxycarbonyl)cyclopropanecarboxylicacid
- Packaging
- 5g
- Price
- $197
- Updated
- 2021/12/16
- Product number
- 160854
- Product name
- 1-Ethoxycarbonylcyclopropane-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $198
- Updated
- 2021/12/16
1-(ethoxycarbonyl)cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Uses
1-(Ethoxycarbonyl)cyclopropanecarboxylic Acid is used in preparation of broad-spectrum anticancer medicine cabozantinib.
Synthesis
1559-02-0
3697-66-3
1-(Ethoxycarbonyl)cyclopropanecarboxylic acid was synthesized as follows: A solution of diethyl 1,1-cyclopropanedicarboxylate (20 g) in 1N NaOH (107 mL) and ethanol (220 mL) was hydrolyzed for 16 hours. Ethanol was removed by decompression distillation. The remaining starting material was extracted with ethyl acetate. The aqueous layer was acidified with 1N HCl. The reaction mixture was then extracted with ethyl acetate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford 1-(ethoxycarbonyl)cyclopropanecarboxylic acid in 94% yield. 1H NMR (CDCl3) δ 1.06 (t, 3H), 1.53 (m, 2H), 1.62 (m, 2H), 4.21 (q, 2H). ESI-MS: m/z 159 [M+H]+ for C7H10O4.
References
[1] Patent: WO2005/79812, 2005, A1. Location in patent: Page/Page column 45-46
[2] Patent: WO2005/79812, 2005, A1. Location in patent: Page/Page column 45-46
[3] Patent: CN105111155, 2018, B. Location in patent: Paragraph 0038; 0051; 0055; 0056
[4] Patent: US2008/45556, 2008, A1. Location in patent: Page/Page column 21
[5] Patent: US2010/239576, 2010, A1
1-(ethoxycarbonyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(ethoxycarbonyl)cyclopropanecarboxylic acid manufacturers
- Product
- 1-(ethoxycarbonyl)cyclopropanecarboxylic acid 3697-66-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- 1-(ethoxycarbonyl)cyclopropanecarboxylic acid 3697-66-3
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- 1-(ethoxycarbonyl)cyclopropanecarboxylic acid 3697-66-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-26